Striatal functional alteration during incentive anticipation in pediatric anxiety disorders.
Striatal functional alteration during incentive anticipation in pediatric anxiety disorders.
复制标题
小儿焦虑症激励预期期间纹状体功能的改变。
DOI：
10.1176/appi.ajp.2011.11010006
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Ernst M
中科院分区：
文献类型：
--
作者：
Guyer AE;Choate VR;Detloff A;Benson B;Nelson EE;Perez-Edgar K;Fox NA;Pine DS;Ernst M
行为抑制是一种早期儿童气质，最近与青春期纹状体对不断增加的刺激的反应改变有关。由于儿童早期的行为抑制也与青少年社交恐惧症的风险有关，因此在社交恐惧症中可能会出现类似的纹状体激活模式。本研究比较了健康青少年、社交恐惧症青少年和广泛性焦虑症青少年的纹状体功能。在58名无药物治疗的青少年中检查了纹状体区域的血氧水平依赖性信号-14名患有社交恐惧症，18名患有广泛性焦虑症但没有社交恐惧症，26名没有精神疾病-在性别，年龄，青春期，智商和社会经济地位上匹配。在功能性磁共振成像过程中，参与者对描述不同程度的潜在货币收益或损失的激励线索做出反应。虽然预期的激励措施越来越大，青少年与社交恐惧症表现出越来越高的尾状核和壳核激活的水平大于健康的比较和广泛性焦虑症组。广泛性焦虑症组表现出独特的价特异性壳核反应相对于健康的比较或社交恐惧症组。两组患者的脑桥核比尾状核或壳核显示出更复杂的模式。尾状核和壳核的超敏反应的激励措施的增加幅度的特点青少年社交恐惧症，相对于激活在这一地区的青少年广泛性焦虑症以及健康的青少年。因此，这些研究结果类似于以前发现的模式，在青少年与儿童早期行为抑制，从而暗示类似的神经反应，以预期的激励在儿童早期行为抑制和青少年社交恐惧症。
Behavioral inhibition is an early childhood temperament recently associated with altered striatal response in adolescence to incentives of increasing magnitudes. Since early childhood behavioral inhibition is also associated with risk for adolescent social phobia, a similar pattern of striatal activation may manifest in social phobia. The present study compares striatal function in healthy adolescents, adolescents with social phobia, and adolescents with generalized anxiety disorder. Blood-oxygen-level-dependent signal in striatal regions was examined in 58 medication-free adolescents—14 with social phobia, 18 with generalized anxiety disorder but not social phobia, and 26 with no psychiatric disorder—matched on sex, age, puberty, IQ, and socioeconomic status. During functional magnetic resonance imaging, participants responded to incentive cues depicting potential monetary gains or losses of varying magnitudes. While anticipating incentives of increasing magnitude, adolescents with social phobia showed increasingly heightened caudate and putamen activation at a level greater than that seen in the healthy comparison and generalized anxiety disorder groups. The generalized anxiety disorder group showed a unique valence-specific putamen response relative to the healthy comparison or social phobia group. Both patient groups displayed more complex patterns in the nucleus accumbens than in the caudate or putamen. Caudate and putamen hypersensitivity to incentives of increasing magnitudes characterizes adolescent social phobia, relative to activation in this region in adolescents with generalized anxiety disorder as well as healthy adolescents. Thus, these findings resemble the pattern previously found in adolescents with early childhood behavioral inhibition, thereby implicating similar neural responses to anticipation of incentives in both early childhood behavioral inhibition and adolescent social phobia.
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影响因子：
2.6
作者：
Helfinstein, Sarah M.;Benson, Brenda;Ernst, Monique
通讯作者：
Ernst, Monique
影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
DOI：
10.1097/chi.0b013e3181ae09df
发表时间：
2009-09
影响因子：
13.3
作者：
Chronis-Tuscano A;Degnan KA;Pine DS;Perez-Edgar K;Henderson HA;Diaz Y;Raggi VL;Fox NA
通讯作者：
Fox NA
影响因子：
5.7
作者：
Cohen, MS
通讯作者：
Cohen, MS