Role of contingency in striatal response to incentive in adolescents with anxiety.
Role of contingency in striatal response to incentive in adolescents with anxiety.
复制标题
意外事件在焦虑青少年纹状体对激励反应中的作用。
DOI：
10.3758/s13415-014-0307-6
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Ernst M
中科院分区：
文献类型：
--
作者：
Benson BE;Guyer AE;Nelson EE;Pine DS;Ernst M
本研究探讨了偶然性对焦虑中奖赏功能的影响。我们将偶然性定义为结果由一个人的行动决定的情况的一个方面，也就是说，当一个人的行动和行动的结果之间存在直接联系时。过去对有焦虑或有焦虑风险的青少年的研究表明，对正确表现的高价值奖励的行为和神经反应过敏。这种对高价值（突出）行动的高度敏感表明，行动的价值不仅取决于结果的大小，还取决于结果取决于正确表现的程度。因此，偶然性和激励价值可能各自以独特的方式调节焦虑中的奖励反应。采用功能磁共振成像（fMRI）和金钱奖励任务，比较了18名临床焦虑青少年和20名健康青少年对线索预期的纹状体反应。该任务对奖励偶然性和激励价值进行正交操作。结果表明，在两组中，偶然性调节对刺激强度的神经反应是不同的。具体而言，在偶然条件下，焦虑但不健康的青少年的右侧纹状体反应跟踪激励价值。在非偶然条件下，焦虑青少年纹状体对低激励的反应比对高激励的反应更强烈，而健康青少年则表现出相反的模式。焦虑青少年纹状体激活与健康青少年纹状体激活之间的偶然性和奖励大小差异。这些发现可能反映了对焦虑青少年的表现和/或纹状体奖励价值编码改变的夸大关注。焦虑的奖励功能异常可能具有治疗意义。
This study examines the effect of contingency on reward function in anxiety. We define contingency as the aspect of a situation in which the outcome is determined by one’s action‒that is, when there is a direct link between one’s action and the outcome of the action. Past findings in adolescents with anxiety or at risk for anxiety have revealed hypersensitive behavioral and neural responses to higher value rewards with correct performance. This hypersensitivity to highly valued (salient) actions suggests that the value of actions is determined not only by outcome magnitude, but also by the degree to which the outcome is contingent on correct performance. Thus, contingency and incentive value might each modulate reward responses in unique ways in anxiety. Using fMRI with a monetary reward task, striatal response to cue anticipation is compared in 18 clinically anxious and 20 healthy adolescents. This task manipulates orthogonally reward contingency and incentive value. Findings suggest that contingency modulates the neural response to incentive magnitude differently in the two groups. Specifically, during the contingent condition, right-striatal response tracks incentive value in anxious, but not healthy, adolescents. During the noncontingent condition, striatal response is bilaterally stronger to low than to high incentive in anxious adolescents, while healthy adolescents exhibit the expected opposite pattern. Both contingency and reward magnitude differentiate striatal activation in anxious versus healthy adolescents. These findings may reflect exaggerated concern about performance and/or alterations of striatal coding of reward value in anxious adolescents. Abnormalities in reward function in anxiety may have treatment implications.
登录
查看更多内容
影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
10.6
作者：
Krain, Amy L.;Gotimer, Kristin;Milham, Michael P.
通讯作者：
Milham, Michael P.
DOI：
10.1111/j.1469-7610.2006.01677.x
发表时间：
2006-10-01
影响因子：
7.6
作者：
Krain, Amy L.;Hefton, Sara;Milham, Michael P.
通讯作者：
Milham, Michael P.
影响因子：
2.6
作者：
Helfinstein, Sarah M.;Benson, Brenda;Ernst, Monique
通讯作者：
Ernst, Monique
DOI：
10.1097/chi.0b013e3181ae09df
发表时间：
2009-09
影响因子：
13.3
作者：
Chronis-Tuscano A;Degnan KA;Pine DS;Perez-Edgar K;Henderson HA;Diaz Y;Raggi VL;Fox NA
通讯作者：
Fox NA