Role of Transforming Growth Factor β in Uterine Fibroid Biology
Role of Transforming Growth Factor β in Uterine Fibroid Biology
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转化生长因子 β 在子宫肌瘤生物学中的作用
DOI：
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发表时间：
2017
影响因子：
5.6
通讯作者：
G. Jakiel
中科院分区：
文献类型：
--
作者：
M. Ciebiera;M. Włodarczyk;M. Wrzosek;B. Męczekalski;G. Nowicka;K. Łukaszuk;M. Ciebiera;A. Słabuszewska;G. Jakiel
子宫肌瘤（UFs）是由子宫平滑肌组成的女性生殖道良性肿瘤。UF的生长主要取决于类固醇激素和选定的生长因子的影响。转化生长因子β (TGF-βs)是一种多肽，由TGF-β1、TGF-β2和TGF-β3三种亚型组成。目前TGF-β被认为是UFs病理生理的关键因子之一。它在肿瘤内的细胞迁移，刺激肿瘤生长，增强肿瘤代谢中起主要作用。由于各种依赖性，UF肿瘤中TGF-β的合成和释放增加，导致过度的细胞外基质产生和储存。TGF-β介质的高浓度或过表达可能是临床症状性UFs的原因。本综述的目的是检查TGF-β家族对UF生物学影响的现有证据。我们在国家医学图书馆的PubMed中进行了搜索，使用以下关键词：“子宫肌瘤”，“平滑肌瘤”和“转化生长因子β”。在审查了标题和摘要之后，对超过115篇完整的文章进行了评估。我们关注TGF-β相关的分子方面及其对与UFs相关的最常见症状的影响。此外，我们还描述了现有数据可能如何影响UFs的当前医疗管理。
Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones and selected growth factors. Transforming growth factor β (TGF-βs) is a polypeptide that consists of three isoforms: TGF-β1, TGF-β2, and TGF-β3. At present, TGF-β is considered to be one of the key factors in the pathophysiology of UFs. It plays a major role in cellular migration within the tumor, stimulates tumor growth, and enhances tumor metabolism. As a consequence of various dependencies, the synthesis and release of TGF-β in a UF tumor is increased, which results in excessive extracellular matrix production and storage. High concentrations or overexpression of TGF-β mediators may be responsible for clinically symptomatic UFs. The aim of this review was to check the available evidence for the influence of the TGF-β family on UF biology. We conducted their search in PubMed of the National Library of Medicine with the use of the following selected keywords: “uterine fibroid”, “leiomyoma”, and “transforming growth factor β”. After reviewing the titles and abstracts, more than 115 full articles were evaluated. We focused on the TGF-β-related molecular aspects and their influence on the most common symptoms that are associated with UFs. Also, we described how the available data might implicate the current medical management of UFs.
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影响因子：
6.7
作者：
Baird, Donna Day;Garrett, Tiana A.;Laughlin, Shannon K.;Davis, Barbara;Semelka, Richard C.;Peddada, Shyamal D.
通讯作者：
Peddada, Shyamal D.
影响因子：
6.7
作者：
Brakta S;Diamond JS;Al-Hendy A;Diamond MP;Halder SK
通讯作者：
Halder SK
与子宫肌瘤相比，平滑肌瘤中转化生长相互作用因子的表达。
影响因子：
6.7
作者：
Yen-PingHo,Jason;Man,WengChi;Wen,Yan;Polan,MaryLake;Shih-ChuHo,Esther;Chen,Bertha
通讯作者：
Chen,Bertha
影响因子：
4.8
作者：
Ishikawa, Hiroshi;Ishi, Kazutomo;Kurita, Takeshi
通讯作者：
Kurita, Takeshi
影响因子：
20.3
作者：
G. Pearson;Fred L Robinson;T. Gibson;Bing-e Xu;M. Karandikar;K. Berman;M. Cobb
通讯作者：
G. Pearson;Fred L Robinson;T. Gibson;Bing-e Xu;M. Karandikar;K. Berman;M. Cobb