Hypothalamic pituitary adrenal axis responses to low-intensity stressors are reduced after voluntary wheel running in rats.
Hypothalamic pituitary adrenal axis responses to low-intensity stressors are reduced after voluntary wheel running in rats.
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DOI：
10.1111/j.1365-2826.2010.02007.x
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发表时间：
2010-08
影响因子：
3.2
通讯作者：
Day HE
中科院分区：
文献类型：
--
作者：
Campeau S;Nyhuis TJ;Sasse SK;Kryskow EM;Herlihy L;Masini CV;Babb JA;Greenwood BN;Fleshner M;Day HE
经常进行体育锻炼对身心健康都有好处。相比之下，压力会对健康产生有害影响，而且越来越多的证据表明，定期体育锻炼可以抵消压力的一些影响。然而，大多数先前的研究表明，先前的锻炼不会改变下丘脑垂体肾上腺（HPA）轴对压力的急性反应。目前的一系列研究提供的证据表明，在大鼠中，6 周（但不是 1 或 3 周）的自愿轮跑会降低 HPA 轴对低强度应激源（如腹腔注射）的反应。注射盐水、暴露于新的环境或暴露于中等强度的噪音，但不要暴露于更强烈的压力源，例如暴露于捕食者的气味或束缚。每天锻炼似乎对于减少 HPA 轴反应不是必需的，间歇性地使用跑轮（每 72 小时中的 24 小时）持续 6 周，会导致促肾上腺皮质激素和皮质酮释放在 85 dBA 噪音暴露下出现类似的减少。来自 c-fos mRNA 原位杂交的数据与以下假设一致：自愿运动导致中枢水平的 HPA 轴对低强度应激源的反应性降低，而初级感觉处理没有变化。总之，这些数据表明，6 周的日常或间歇性运动会限制 HPA 轴对轻微压力的反应，但不会限制更强烈的压力，并且这种调节可能是在主要感觉输入之外的中枢水平上介导的。
Regular physical exercise is beneficial for both physical and mental health. By contrast, stress is associated with deleterious effects on health and there is growing evidence that regular physical exercise counteracts some of the effects of stress. However, most previous studies have suggested that prior exercise does not alter the acute hypothalamic pituitary adrenal (HPA) axis responses to stress. The present series of studies provides evidence that in rats, 6 weeks (but not 1 or 3 weeks) of voluntary wheel running reduces the HPA axis responses to lower-intensity stressors such as an i.p. saline injection, exposure to a novel environment or exposure to moderate intensity noise, but not to more intense stressors such as predator odour exposure or restraint. Daily exercise does not appear to be necessary for the reduction in HPA axis responses, with intermittent access (24 h out of each 72-h period) to a running wheel for 6 weeks, resulting in similar decrements in adrenocorticotrophic hormone and corticosterone release in response to 85 dBA noise exposure. Data from in situ hybridisation for c-fos mRNA are consistent with the hypothesis that voluntary exercise results in a decrease in HPA axis responsiveness to a low-intensity stressor at a central level, with no changes in primary sensory processing. Together, these data suggest that 6 weeks of daily or intermittent exercise constrains the HPA axis response to mild, but not more intense stressors, and that this regulation may be mediated at a central level beyond the primary sensory input.
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影响因子：
3.3
作者：
Fediuc, Sergiu;Campbell, Jonathan E.;Riddell, Michael C.
通讯作者：
Riddell, Michael C.
影响因子：
2.9
作者：
Greenwood, BN;Foley, TE;Fleshner, M
通讯作者：
Fleshner, M
影响因子：
5.4
作者：
Lett, BT;Grant, VL;Koh, MT
通讯作者：
Koh, MT
DOI：
10.1152/ajpregu.00513.2002
发表时间：
2003-02-01
影响因子：
2.8
作者：
Campisi, J;Leem, TH;Fleshner, M
通讯作者：
Fleshner, M
影响因子：
3.4
作者：
Day, HEW;Nebel, S;Campeau, S
通讯作者：
Campeau, S