Current gene expression studies in esophageal carcinoma.
Current gene expression studies in esophageal carcinoma.
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当前食管癌基因表达研究
DOI：
10.2174/138920209789503888
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发表时间：
2009-12
期刊：
影响因子：
2.6
通讯作者：
Jiang YG
中科院分区：
文献类型：
--
作者：
Guo W;Jiang YG
食管癌是最致命的癌症之一，具有高度侵袭性，在全球男性中排名第六，在女性中排名第九。食管癌由于早期发生转移和周围组织的浸润，其5年总生存率（14%）与20世纪70年代以来的低生存率（4%）相比仍然很低。食管癌的发生发展涉及到许多基因和蛋白的表达和功能异常，但具体过程尚不清楚。基因芯片技术已应用于食管癌的研究。许多基因表达的研究已经进行了食管癌基因转录水平的特定模式。人类组织和细胞系被用于这些基因谱研究，并且从各种微阵列实验中产生了一组非常有价值和有趣的数据。这些表达的研究提供了更多的了解复杂的病理机制参与食管癌。微阵列的最终目标是发现新的治疗标记物，并根据个体肿瘤遗传组成定制治疗。本文就食管癌基因表达谱的研究现状作一综述。
Esophageal carcinoma is one of the deadliest cancers with highly aggressive potency, ranking as the sixth most common cancer among males and ninth most common cancer among females globally. Due to metastasis and invasion of surrounding tissues in early stage, the 5-year overall survival rate (14%) of esophageal cancer remains poor, even in comparison with the dismal survival rates (4%) from the 1970s. Numerous genes and proteins with abnormal expression and function involve in the pathogenesis of esophageal cancer, but the concrete process remains unclear. Microarray technique has been applied to investigating esophageal cancer. Many gene expression studies have been undertaken to look at the specific patterns of gene transcript levels in esophageal cancer. Human tissues and cell lines were used in these geneprofiling studies and a very valuable and interesting set of data has resulted from various microarray experiments. These expression studies have provided increased understanding of the complex pathological mechanisms involved in esophageal cancer. The eventual goal of microarray is to discover new markers for therapy and to customize therapy based on an individual tumor genetic composition. This review summarized the current state of gene expression profile studies in esophageal cancer.
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