Distribution of nanoparticles in the see-through medaka (Oryzias latipes).
Distribution of nanoparticles in the see-through medaka (Oryzias latipes).
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DOI：
10.1289/ehp.9209
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发表时间：
2006-11
影响因子：
10.4
通讯作者：
Kashiwada S
中科院分区：
文献类型：
--
作者：
Kashiwada S
由于制造的纳米颗粒的环境命运被认为是一个新兴的环境问题，我使用水悬浮的荧光纳米颗粒（固体乳胶溶液）来研究纳米颗粒在透明青鳉（Oryzias latipes）的卵和身体中的分布。直径为39.4- 42，000 nm的颗粒吸附在青鳉卵的绒毛膜上并积累在油滴中; 474 nm的颗粒对卵的生物利用度最高。在胚胎发育过程中，直径为39.4 nm的颗粒进入卵黄和胆囊。当暴露于10 mg/L的纳米颗粒溶液时，成年青鳉主要在鳃和肠中积累39.4 nm的纳米颗粒。在大脑、睾丸、肝脏和血液中也检测到了纳米颗粒。雄性和雌性青鳉血液中纳米颗粒的浓度分别为16.5和10.5 ng/mg血液蛋白。这些结果表明，纳米颗粒能够穿透血脑屏障，并最终到达大脑。在暴露于纳米颗粒24小时的青鳉卵中观察到盐度依赖性急性毒性。纳米粒的生物利用度和毒性取决于环境因素和多种理化性质。有必要进一步研究商业产品中使用的纳米颗粒的毒性效应及其环境相关性，以确定纳米材料应用的风险和益处。
Because the environmental fate of manufactured nanoparticles is considered an emerging environmental concern, I used water-suspended fluorescent nanoparticles (solid latex solution) to investigate the distribution of nanoparticles in the eggs and bodies of see-through medaka (Oryzias latipes). Particles 39.4–42,000 nm in diameter were adsorbed to the chorion of medaka eggs and accumulated in the oil droplets; 474-nm particles had the highest bioavailability to eggs. Particles 39.4 nm in diameter shifted into the yolk and gallbladder during embryonic development. Adult medaka accumulated 39.4-nm nanoparticles mainly in the gills and intestine when exposed to a 10-mg/L nanoparticle solution. Nanoparticles were also detected in the brain, testis, liver, and blood. Concentrations of nanoparticles in the blood of male and female medaka were 16.5 and 10.5 ng/mg blood protein, respectively. These results suggest that nanoparticles are capable of penetrating the blood–brain barrier and that they eventually reach the brain. Salinity-dependent acute toxicity was observed in medaka eggs exposed for 24 hr to nanoparticles. The bioavailability and toxicity of nanoparticles depend on environmental factors and multiple physicochemical properties. Further studies on the toxic effects of nanoparticles used in commercial products and their environmental relevance, are necessary to define the risks and benefit of nanomaterial applications.
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影响因子：
10.4
作者：
Hardman R
通讯作者：
Hardman R
影响因子：
11.4
作者：
Jia, G;Wang, HF;Guo, XB
通讯作者：
Guo, XB
影响因子：
46.9
作者：
Colvin, VL
通讯作者：
Colvin, VL
DOI：
10.1016/s1383-5718(03)00133-5
发表时间：
2003-08-05
影响因子：
1.9
作者：
Liu, Z;Kullman, SW;Hinton, DE
通讯作者：
Hinton, DE
影响因子：
3.8
作者：
Braydich-Stolle, L;Hussain, S;Hofmann, MC
通讯作者：
Hofmann, MC