Sexually selected traits: a fundamental framework for studies on behavioral epigenetics.
Sexually selected traits: a fundamental framework for studies on behavioral epigenetics.
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DOI：
10.1093/ilar.53.3-4.253
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发表时间：
2012
期刊：
影响因子：
2.5
通讯作者：
Rosenfeld CS
中科院分区：
文献类型：
--
作者：
Jašarević E;Geary DC;Rosenfeld CS
新出现的证据表明，基于表观遗传的机制导致了大脑和行为方面的性别差异。建立和充分理解这种联系的主要障碍是确定最易受表观遗传修饰影响的性状。我们已经提出，性选择为识别这些特征提供了一个概念性框架。这些特征涉及两性间的配偶竞争和交配伙伴的两性选择，通常需要男性-男性竞争和女性选择的组合。这些行为是在早期胚胎和出生后发育期间，特别是在从少年到成年的过渡时期，通过大脑暴露于类固醇激素，包括雌二醇和睾酮而编程的。我们评估了包括双酚A在内的内分泌干扰化合物可以干扰重要的表观遗传和基因表达途径以及具有可能控制这些特征表达的表观遗传机制的性选择特征的阐述的证据。最后，我们回顾了这些证据，表明这些类固醇激素可以在大脑中诱导各种表观遗传变化，包括DNA甲基化的程度，组蛋白变化，甚至非编码RNA的变化，并且许多变化在男性和女性之间有所不同。虽然之前的很多注意力都集中在生殖行为中的初级性别差异上，如男性配种和女性前凸，但我们概述了为什么与竞争和配偶选择相关的次要性别差异也可能追溯到类固醇诱导的大脑不同区域的表观遗传编程。
Emerging evidence suggests that epigenetic-based mechanisms contribute to various aspects of sex differences in brain and behavior. The major obstacle in establishing and fully understanding this linkage is identifying the traits that are most susceptible to epigenetic modification. We have proposed that sexual selection provides a conceptual framework for identifying such traits. These are traits involved in intrasexual competition for mates and intersexual choice of mating partners and generally entail a combination of male–male competition and female choice. These behaviors are programmed during early embryonic and postnatal development, particularly during the transition from the juvenile to adult periods, by exposure of the brain to steroid hormones, including estradiol and testosterone. We evaluate the evidence that endocrine-disrupting compounds, including bisphenol A, can interfere with the vital epigenetic and gene expression pathways and with the elaboration of sexually selected traits with epigenetic mechanisms presumably governing the expression of these traits. Finally, we review the evidence to suggest that these steroid hormones can induce a variety of epigenetic changes in the brain, including the extent of DNA methylation, histone protein alterations, and even alterations of noncoding RNA, and that many of the changes differ between males and females. Although much previous attention has focused on primary sex differences in reproductive behaviors, such as male mounting and female lordosis, we outline why secondary sex differences related to competition and mate choice might also trace their origins back to steroid-induced epigenetic programming in disparate regions of the brain.
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DOI：
10.1073/pnas.0610410104
发表时间：
2007-04-03
影响因子：
11.1
作者：
Crews, David;Gore, Andrea C.;Skinner, Michael K.
通讯作者：
Skinner, Michael K.
影响因子：
2.5
作者：
Cantoni, D;Brown, RE
通讯作者：
Brown, RE
影响因子：
3.5
作者：
Bredy, TW;Lee, AW;Brown, RE
通讯作者：
Brown, RE
大脑和行为的表观遗传修饰：理论与实践。
影响因子：
3.5
作者：
Crews, David
通讯作者：
Crews, David
DOI：
10.1073/pnas.1100314108
发表时间：
2011-03-08
影响因子：
11.1
作者：
Auger, Catherine J.;Coss, Dylan;Forbes-Lorman, Robin M.
通讯作者：
Forbes-Lorman, Robin M.