The amazing and anomalous axolotls as scientific models.
The amazing and anomalous axolotls as scientific models.
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DOI：
10.1002/dvdy.470
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发表时间：
2022-06
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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钝口蝾螈胚胎和幼体作为模式生物用于发育和再生研究已有多年。这种幼态水生物种保持着独特的能力，即使不是全部，也能再生大部分组织，直到成年。蝾螈具有巨大的外部发育胚胎，是发育生物学的原始模式物种之一。然而，越来越多的访问和使用，生物体的测序和注释的基因组，如非洲爪蟾和热带和Danio rerio，减少了流行的蝾螈作为模型在胚胎发生研究。最近对大蝾螈基因组的测序为定义驱动四肢和脊髓等组织形成和再生的配方开辟了新的可能性。然而，要解码大A.墨西哥的基因组将需要巨大的努力，社区资源，和新技术的发展。在这里，我们提供了一个更新的蝾螈分期图表，从单细胞阶段到未成熟的成年人，结合历史和当前蝾螈研究的角度，从它们在早期发展研究中的应用到最近的前沿研究，转基因的就业，高分辨率成像和再生机制的研究。
Ambystoma mexicanum (axolotl) embryos and juveniles have been used as model organisms for developmental and regenerative research for many years. This neotenic aquatic species maintains the unique capability to regenerate most, if not all, of its tissues well into adulthood. With large externally developing embryos, axolotls were one of the original model species for developmental biology. However, increased access to, and use of, organisms with sequenced and annotated genomes, such as Xenopus laevis and tropicalis and Danio rerio, reduced the prevalence of axolotls as models in embryogenesis studies. Recent sequencing of the large axolotl genome opens up new possibilities for defining the recipes that drive the formation and regeneration of tissues like the limbs and spinal cord. However, to decode the large A. mexicanum genome will take a herculean effort, community resources, and the development of novel techniques. Here, we provide an updated axolotl-staging chart ranging from one-cell stage to immature adult, paired with a perspective on both historical and current axolotl research that spans from their use in early studies of development to the recent cutting-edge research, employment of transgenesis, high-resolution imaging, and study of mechanisms deployed in regeneration.
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影响因子：
4.1
作者：
Boisvert CA;Joss JM;Ahlberg PE
通讯作者：
Ahlberg PE
DOI：
10.1002/advs.202100407
发表时间：
2021-08
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Durant F;Whited JL
通讯作者：
Whited JL
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.5
作者：
Demircan, Turan;Ilhan, Ayse Elif;Keskin, Ilknur
通讯作者：
Keskin, Ilknur
影响因子：
3.3
作者：
Demircan, Turan;Hacibektasogu, Harbiye;Suzek, Baris Ethem
通讯作者：
Suzek, Baris Ethem