Wistar-Kyoto rats as an animal model of anxiety vulnerability: support for a hypervigilance hypothesis.
Wistar-Kyoto rats as an animal model of anxiety vulnerability: support for a hypervigilance hypothesis.
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DOI：
10.1016/j.bbr.2009.05.036
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发表时间：
2009-12-01
影响因子：
2.7
通讯作者：
Pang, K. C. H.
中科院分区：
文献类型：
--
作者：
McAuley, J. D.;Stewart, A. L.;Webber, E. S.;Cromwell, H. C.;Servatius, R. J.;Pang, K. C. H.
近交 Wistar-Kyoto (WKY) 大鼠被认为是焦虑脆弱性的模型，因为与远交 Sprague-Dawley (SD) 大鼠相比，它们表现出行为抑制以及一系列学习和反应异常。总之，WKY 大鼠的行为表明，过度警惕状态可能会导致其焦虑脆弱性。为了检验这一假设，对 WKY 和 Sprague Dawley (SD) 大鼠的旷场行为、声惊吓、预脉冲抑制和计时行为进行了评估。使用峰值间隔计时程序的修改版本来评估计时行为。计时训练和测试首先在没有视听 (AV) 干扰的情况下进行。在此初步测试之后，一些试验中纳入了 AV 干扰。总体而言，与 SD 大鼠相比，WKY 大鼠离开场地中心的时间要长得多，越线次数和饲养次数也更少。与 SD 大鼠相比，WKY 大鼠对声刺激表现出更大的惊吓反应，并且显着更强的前脉冲抑制。在没有 AV 干扰的计时条件下，两种菌株的计时精度相似； WKY 和 SD 大鼠的峰值时间没有不同。然而，在干扰条件下，两种菌株的计时行为非常不同。尽管 SD 大鼠在无干扰和干扰条件下的峰值时间相似，但与无干扰条件相比，WKY 大鼠在干扰条件下的峰值时间更短且响应率更高。增强的听觉惊吓反应、更大的前脉冲抑制和视听干扰改变的计时行为支持 WKY 菌株的过度警觉特征，并为使用 WKY 菌株作为焦虑脆弱性模型提供了进一步的证据。
Inbred Wistar-Kyoto (WKY) rats have been proposed as a model of anxiety vulnerability as they display behavioral inhibition and a constellation of learning and reactivity abnormalities relative to outbred Sprague-Dawley (SD) rats. Together, the behaviors of the WKY rat suggest a hypervigilant state may contribute to its anxiety vulnerability. To test this hypothesis, open-field behavior, acoustic startle, pre-pulse inhibition and timing behavior were assessed in WKY and Sprague Dawley (SD) rats. Timing behavior was evaluated using a modified version of the peak-interval timing procedure. Training and testing of timing first occurred without audio-visual (AV) interference. Following this initial test, AV interference was included on some trials. Overall, WKY rats took much longer to leave the center of the arena, made fewer line crossings, and reared less, than did SD rats. WKY rats showed much greater startle responses to acoustic stimuli and significantly greater pre-pulse inhibition than did the SD rats. During timing conditions without AV interference, timing accuracy for both strains were similar; peak times for WKY and SD rats were not different. During interference conditions, however, the timing behavior of the two strains was very different. Whereas peak times for SD rats were similar between non-interference and interference conditions, peak times for WKY rats were shorter and response rates higher in interference conditions than in non-interference conditions. The enhanced acoustic startle response, greater prepulse inhibition and altered timing behavior with audio-visual interference supports a characterization of WKY strain as hypervigilant and provides further evidence for the use of the WKY strain as a model of anxiety vulnerability.
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