Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?
Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?
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ADHD 冲动性和 BMI 是否具有共同的多基因和神经相关性？
DOI：
10.1038/s41380-019-0444-y
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发表时间：
2021-03
影响因子：
11
通讯作者：
IMAGEN Consortium
中科院分区：
文献类型：
--
作者：
Barker ED;Ing A;Biondo F;Jia T;Pingault JB;Du Rietz E;Zhang Y;Ruggeri B;Banaschewski T;Hohmann S;Bokde ALW;Bromberg U;Büchel C;Quinlan EB;Sounga-Barke E;Bowling AB;Desrivières S;Flor H;Frouin V;Garavan H;Asherson P;Gowland P;Heinz A;Ittermann B;Martinot JL;Martinot MP;Nees F;Papadopoulos-Orfanos D;Poustka L;Smolka MN;Vetter NC;Walter H;Whelan R;Schumann G;IMAGEN Consortium
有大量的文献将ADHD与超重和肥胖联系起来。研究表明，ADHD的冲动特征在一定程度上解释了这种重叠。这种关联的神经和多基因相关性尚未得到彻底的研究。在IMAGEN研究的参与者中，我们发现冲动症状和体重指数（BMI）相关（r = 0.10，n = 874，p = 0.014 FWE校正），他们各自的多基因风险评分（PRS）也是如此（r = 0.17，n = 874，p = 6.5 × 10−6 FWE校正）。然后，我们研究了冲动性和BMI的表型，以及ADHD和BMI的PRS评分，是否与全脑灰质和与奖励相关的冲动性相关的金钱激励延迟fMRI任务有共同的关联。稀疏偏最小二乘分析（sPLS）揭示了一个共同的神经基板，与表型和PRS评分。在最后一步中，我们进行了偏差校正自举中介分析与神经基板得分从sPLS作为调解人。ADHD PRS与冲动症状（B = 0.006，90% CI = 0.001，0.019）和BMI（B = 0.009，90% CI = 0.001，0.025）通过神经影像学底物相关。BMI PRS与BMI（B = 0.014，95%CI = 0.003，0.033）和冲动症状（B = 0.009，90%CI = 0.001，0.025）通过神经影像学底物相关。一个共同的神经基质可能（部分）支持ADHD和BMI的共同遗传易感性及其（可观察到的）表型关联的表现。
There is an extensive body of literature linking ADHD to overweight and obesity. Research indicates that impulsivity features of ADHD account for a degree of this overlap. The neural and polygenic correlates of this association have not been thoroughly examined. In participants of the IMAGEN study, we found that impulsivity symptoms and body mass index (BMI) were associated (r = 0.10, n = 874, p = 0.014 FWE corrected), as were their respective polygenic risk scores (PRS) (r = 0.17, n = 874, p = 6.5 × 10−6 FWE corrected). We then examined whether the phenotypes of impulsivity and BMI, and the PRS scores of ADHD and BMI, shared common associations with whole-brain grey matter and the Monetary Incentive Delay fMRI task, which associates with reward-related impulsivity. A sparse partial least squared analysis (sPLS) revealed a shared neural substrate that associated with both the phenotypes and PRS scores. In a last step, we conducted a bias corrected bootstrapped mediation analysis with the neural substrate score from the sPLS as the mediator. The ADHD PRS associated with impulsivity symptoms (b = 0.006, 90% CIs = 0.001, 0.019) and BMI (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. The BMI PRS associated with BMI (b = 0.014, 95% CIs = 0.003, 0.033) and impulsivity symptoms (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. A common neural substrate may (in part) underpin shared genetic liability for ADHD and BMI and the manifestation of their (observable) phenotypic association.
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影响因子：
2.7
作者：
Fazzari, Gilda;Zizza, Merylin;Canonaco, Marcello
通讯作者：
Canonaco, Marcello
影响因子：
6.9
作者：
Frazier-Wood, Alexis C.;Carnell, Susan;Pena, Oscar;Hughes, Sheryl O.;O'Connor, Teresia M.;Asherson, Philip;Kuntsi, Jonna
通讯作者：
Kuntsi, Jonna
DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
3.3
作者：
Chamberlain SR;Ioannidis K;Leppink EW;Niaz F;Redden SA;Grant JE
通讯作者：
Grant JE
影响因子：
3.7
作者：
Grabenhorst, Fabian;Rolls, Edmund T.;Bilderbeck, Amy
通讯作者：
Bilderbeck, Amy