Venom proteins of the parasitoid wasp Nasonia vitripennis: recent discovery of an untapped pharmacopee.

Venom proteins of the parasitoid wasp Nasonia vitripennis: recent discovery of an untapped pharmacopee.
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DOI:
10.3390/toxins2040494
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发表时间:
2010-04
期刊:
影响因子:
4.2
通讯作者:
de Graaf DC
de Graaf DC
中科院分区:
医学2区
文献类型:
--
作者:
Danneels EL;Rivers DB;de Graaf DC

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丽纹夜蛾成虫在产卵前向寄主果蝇注射有毒混合物。最近,这种体外寄生蜂的整个基因组被测序,从而能够鉴定出79种毒液蛋白。下一个挑战将是解开它们的具体功能,但基于同源研究,已经可以做出一些预测。寄生对寄主生理有很大的影响,本文讨论了寄生对免疫反应、诱导发育停滞、脂质水平升高、细胞凋亡和营养物质释放的影响。文中还讨论了破译这种毒液的价值。
Adult females of Nasonia vitripennis inject a venomous mixture into its host flies prior to oviposition. Recently, the entire genome of this ectoparasitoid wasp was sequenced, enabling the identification of 79 venom proteins. The next challenge will be to unravel their specific functions, but based on homolog studies, some predictions already can be made. Parasitization has an enormous impact on hosts physiology of which five major effects are discussed in this review: the impact on immune responses, induction of developmental arrest, increases in lipid levels, apoptosis and nutrient releases. The value of deciphering this venom is also discussed.
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