Comparison of muscle force after immediate and delayed reinnervation using nerve-muscle-endplate band grafting.
Comparison of muscle force after immediate and delayed reinnervation using nerve-muscle-endplate band grafting.
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DOI：
10.1016/j.jss.2012.02.055
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Mu L
中科院分区：
文献类型：
--
作者：
Sobotka S;Mu L
由于目前使用的神经再支配方法的功能效果差，我们开发了一种新的治疗策略来恢复瘫痪的肌肉-神经-肌肉-终板带移植（NMEG）技术。移植物取自胸骨舌骨肌（SH）（供体）并植入同侧麻痹的胸锁乳突肌（SM）（受体）。大鼠进行立即或延迟（1或3个月）的神经再支配的实验瘫痪SM肌肉使用NMEG技术或传统使用的神经端端吻合术（EEA）。对侧SM肌作为正常对照。与EEA相比，NMEG产生更好的肌力恢复。对于小刺激电流，NMEG产生的较大力最明显。NMEG技术具有成功的肌肉神经再支配的巨大潜力。我们假设，更好的肌肉神经再支配和功能恢复可以实现与环境的进一步改善，有利于轴突终板连接和加速轴突生长和发芽。
Because of poor functional outcomes of currently used reinnervation methods, we developed novel treatment strategy for the restoration of paralyzed muscles - the nerve-muscle-endplate band grafting (NMEG) technique. The graft was obtained from the sternohyoid (SH) muscle (donor) and implanted into the ipsilateral paralyzed sternomastoid (SM) muscle (recipient). Rats were subjected to immediate or delayed (1 or 3 months) reinnervation of the experimentally paralyzed SM muscles using the NMEG technique or the conventionally used nerve end-to-end anastomosis (EEA). The SM muscle at the opposite side served as a normal control. NMEG produced better recovery of muscle force as compared to EEA. A larger force produced by NMEG was most evident for small stimulation currents. The NMEG technique holds great potential for successful muscle reinnervation. We hypothesize that even better muscle reinnervation and functional recovery could be achieved with further improvement of the environment that favors axon-endplate connections and accelerates axonal growth and sprouting.
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影响因子：
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作者：
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