Enhancement of mechanical and biological properties of calcium phosphate bone cement by incorporating bacterial cellulose

Enhancement of mechanical and biological properties of calcium phosphate bone cement by incorporating bacterial cellulose
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通过掺入细菌纤维素增强磷酸钙骨水泥的机械​​和生物性能

DOI:
10.1080/10667857.2019.1630951
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发表时间:
2019-06
影响因子:
3.1
通讯作者:
Luo Honglin
Luo Honglin
中科院分区:
材料科学4区
文献类型:
--
作者:
Zhang Quanchao;Lei Zhili;Peng Mengxia;Zhong Meiling;Wan Yizao;Luo Honglin

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摘要磷酸钙骨水泥(CPC)机械强度低限制了其作为骨替代材料的临床应用。在此,我们首次选择细菌纤维素(BC)纤维来增强CPC。制备了不同BC含量的BC增强CPC(BC/CPC)复合材料,并对其微观结构、抗压强度和细胞反应进行了比较。扫描电子显微镜(SEM)图像显示,在CPC基体中的BC均匀分散。傅里叶变换红外光谱(FTIR)和X射线光电子能谱(XPS)结果证实了BC和CPC之间的界面配位作用。结果表明,BC的引入提高了CPC的抗压强度,最佳BC含量为2 wt.%。此外,电池研究表明,BC/CPC复合材料表现出更好的电池性能比裸CPC。结果表明,以BC为增强体,可开发出力学性能和细胞响应性能均得到增强的新型CPC复合材料。
ABSTRACT Low mechanical strength of calcium phosphate cement (CPC) limits its clinical application as a bone replacement. Herein, for the first time, we selected bacterial cellulose (BC) fibres to reinforce CPC. The BC-reinforced CPC (BC/CPC) composites with varying BC content were prepared and compared in terms of microstructure, compressive strength and cellular responses. Scanning electron microscope (SEM) images revealed the uniform dispersion of BC in CPC matrix. Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) results confirmed the interfacial coordination interaction between BC and CPC. It was found that the introduction of BC enhanced the compressive strength of CPC, and the optimal BC content was 2 wt.%. Moreover, cell studies showed that BC/CPC composites exhibited better cell performance than bare CPC. The results have demonstrated that a new CPC composite with enhanced mechanical performance and cellular responses may be developed by using BC as reinforcement.
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