Ancillary Activity: Beyond Core Metabolism in Immune Cells.
Ancillary Activity: Beyond Core Metabolism in Immune Cells.
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DOI:
10.1016/j.cmet.2017.06.019
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发表时间:
2017-07-05
期刊:
影响因子:
29
通讯作者:
Pearce EL
中科院分区:
文献类型:
--
作者:
Puleston DJ;Villa M;Pearce EL
Immune cell function and fate is intimately linked to engagement of metabolic pathways. The contribution of core metabolic pathways to immune cell bioenergetics has been vigorously investigated in recent years. However, precisely how other peripheral metabolic pathways support immune cells beyond energy generation is less well understood. Here we survey the literature and highlight recent advances in our understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity.
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