Calcium channels and their role in regenerative medicine.
Calcium channels and their role in regenerative medicine.
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DOI：
10.4252/wjsc.v13.i4.260
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发表时间：
2021-04-26
影响因子：
4.1
通讯作者：
Singh BB
中科院分区：
文献类型：
--
作者：
Ahamad N;Singh BB
干细胞具有无限的自我更新能力，可以分化成所有所需的细胞类型。根据其可塑性潜力，它们被分为全能（桑葚阶段细胞）、多能（胚胎干细胞）、多能（造血干细胞、多能成体祖干细胞和间充质干细胞[MSC]）和单能（分化为单一谱系的祖细胞）细胞。虽然骨髓是成人多能干细胞的主要来源，但其他组织，如脂肪组织、胎盘、羊水、脐带血、牙周膜和牙髓也含有可用于再生治疗的干细胞。此外，诱导多能干细胞还表现出自我更新和分化为特化细胞的基本特性，因此可能成为再生医学的另一个来源。包括神经退行性疾病、心血管疾病、自身免疫性疾病、病毒感染（以及 2019 年冠状病毒病）在内的多种疾病传统医学的成功有限，而干细胞移植被认为是治疗这些疾病的最佳疗法。重要的是，间充质干细胞由于其有限的免疫调节和充分的组织修复，是迄今为止再生医学的最佳选择。此外，间充质干细胞具有向受损区域迁移的潜力，这受到多种因素和信号传导过程的调节。最近的研究表明，细胞外钙（Ca2+）可促进间充质干细胞的增殖，从而有助于移植治疗。 Ca2+ 信号传导是一种高度适应性的细胞内信号，包含多种成分，如细胞表面受体、Ca2+ 通道/泵/交换器、Ca2+ 缓冲剂和 Ca2+ 传感器，这些成分对于干细胞的正常功能至关重要，从而调节其增殖和再生能力，本综述将对此进行讨论。
Stem cells hold indefinite self-renewable capability that can be differentiated into all desired cell types. Based on their plasticity potential, they are divided into totipotent (morula stage cells), pluripotent (embryonic stem cells), multipotent (hematopoietic stem cells, multipotent adult progenitor stem cells, and mesenchymal stem cells [MSCs]), and unipotent (progenitor cells that differentiate into a single lineage) cells. Though bone marrow is the primary source of multipotent stem cells in adults, other tissues such as adipose tissues, placenta, amniotic fluid, umbilical cord blood, periodontal ligament, and dental pulp also harbor stem cells that can be used for regenerative therapy. In addition, induced pluripotent stem cells also exhibit fundamental properties of self-renewal and differentiation into specialized cells, and thus could be another source for regenerative medicine. Several diseases including neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, virus infection (also coronavirus disease 2019) have limited success with conventional medicine, and stem cell transplantation is assumed to be the best therapy to treat these disorders. Importantly, MSCs, are by far the best for regenerative medicine due to their limited immune modulation and adequate tissue repair. Moreover, MSCs have the potential to migrate towards the damaged area, which is regulated by various factors and signaling processes. Recent studies have shown that extracellular calcium (Ca2+) promotes the proliferation of MSCs, and thus can assist in transplantation therapy. Ca2+ signaling is a highly adaptable intracellular signal that contains several components such as cell-surface receptors, Ca2+ channels/pumps/exchangers, Ca2+ buffers, and Ca2+ sensors, which together are essential for the appropriate functioning of stem cells and thus modulate their proliferative and regenerative capacity, which will be discussed in this review.
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影响因子：
3.3
作者：
Ding, Dah-Ching;Shyu, Woei-Cherng;Lin, Shinn-Zong
通讯作者：
Lin, Shinn-Zong
DOI：
10.1016/j.bcmd.2020.102492
发表时间：
2021-03
期刊：
Blood cells, molecules & diseases
影响因子：
--
作者：
Broxmeyer HE;Capitano ML;Cooper S;Potchanant ES;Clapp DW
通讯作者：
Clapp DW
影响因子：
4.8
作者：
El-Helw, Mohamed;Chelvarajan, Lakshman;Abdel-Latif, Ahmed
通讯作者：
Abdel-Latif, Ahmed
影响因子：
2.6
作者：
Dimomeletis, Ilias;Deindl, Elisabeth;Franz, Wolfgang M.
通讯作者：
Franz, Wolfgang M.
DOI：
10.1007/978-94-007-7500-8_4
发表时间：
2013-01-01
期刊：
Metal ions in life sciences
影响因子：
--
作者：
Brini, Marisa;Ottolini, Denis;Carafoli, Ernesto
通讯作者：
Carafoli, Ernesto