Prevalence of goiter and thyroid nodules before and after implementation of the universal salt iodization program in mainland China from 1985 to 2014: a systematic review and meta-analysis.
Prevalence of goiter and thyroid nodules before and after implementation of the universal salt iodization program in mainland China from 1985 to 2014: a systematic review and meta-analysis.
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1985-2014年中国大陆全民食盐加碘计划实施前后甲状腺肿和甲状腺结节患病率的系统评价和荟萃分析
DOI：
10.1371/journal.pone.0109549
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Teng W
中科院分区：
文献类型：
--
作者：
Zhao W;Han C;Shi X;Xiong C;Sun J;Shan Z;Teng W
本研究综合评估了中国大陆全民食盐加碘（USI）计划实施前后甲状腺肿和甲状腺结节（TN）的患病率，为制定有效的卫生政策提供信息。检索PubMed、Google Scholar、CNKI、中国万方和重庆维普数据库1985年1月至2014年2月的相关研究。来自合格引文的数据由两名独立评审员提取。所有分析均使用Stata 11.0和SPSS 17.0进行。符合条件的文献（N = 31; 4篇英文文献，27篇中文文献）包括52项研究（1996年之前15项关于甲状腺肿大率，14项之后，23项关于TN）。 我们的荟萃分析表明，1996年前后甲状腺肿和TN的合并患病率分别为22.8%（95% CI：15.3%，30.3%），12.6%（95% CI：9.4%，15.8%）和22.7%（95% CI：18.3%，27.0%）。三个独立类别的Egger检验显示无发表偏倚证据（分别为p=0.101、0.148和0.113）。 1996年后，中国大陆的甲状腺肿患病率下降了近一半，因此认为USI计划是有益的。然而，亚组分析表明，碘不足和过量都可能与甲状腺肿有关。2002年后甲状腺肿和TN的患病率显著增加，表明存在碘摄入过量的风险。因此，应因地制宜地制定食盐加碘标准。
We comprehensively estimated the prevalence of goiter and thyroid nodules (TNs) before and after the implementation of the Universal Salt Iodization (USI) program in mainland China and provided information for creating effective health policies. PubMed, Google Scholar, CNKI, Chinese Wanfang and Chongqing VIP databases were searched for relevant studies from Jan 1985 to Feb 2014. Data from eligible citations were extracted by two independent reviewers. All analyses were performed with Stata 11.0 and SPSS 17.0. Eligible articles (N = 31; 4 in English and 27 in Chinese) included 52 studies (15 about goiter rates made before 1996 and 14 afterwards, and 23 about TNs). Our meta-analysis suggests a pooled prevalence for goiter before and after 1996 and for TNs of 22.8% (95% CI: 15.3%, 30.3%), 12.6% (95% CI: 9.4%, 15.8%) and 22.7% (95% CI: 18.3%, 27.0%), respectively. Egger's test of three independent categories revealed no evidence of publication bias (p = 0.101, 0.148 and 0.113, respectively). The prevalence of goiter was reduced by almost half after 1996 in mainland China, so the USI program was considered beneficial. However, subgroup analysis suggests that both insufficient and excess iodine may be associated with goiter. The prevalence of goiter and TNs increased significantly after 2002, suggesting a risk of excessive iodine intake. Thus, salt iodization standardizations should be set according to local conditions.
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影响因子：
5.8
作者：
LEMAR, HJ;GEORGITIS, WJ;MCDERMOTT, MT
通讯作者：
MCDERMOTT, MT
影响因子：
7.1
作者：
Chen, Zexin;Xu, Weimin;Yu, Yunxian
通讯作者：
Yu, Yunxian
影响因子：
15.8
作者：
Liberati A;Altman DG;Tetzlaff J;Mulrow C;Gøtzsche PC;Ioannidis JP;Clarke M;Devereaux PJ;Kleijnen J;Moher D
通讯作者：
Moher D
影响因子：
5.4
作者：
Gharib, H.;Papini, E.;Vitti, P.
通讯作者：
Vitti, P.
影响因子：
3.2
作者：
Knudsen, N;Bülow, I;Perrild, H
通讯作者：
Perrild, H