Monaural deprivation disrupts development of binaural selectivity in auditory midbrain and cortex.
Monaural deprivation disrupts development of binaural selectivity in auditory midbrain and cortex.
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DOI：
10.1016/j.neuron.2010.02.019
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发表时间：
2010-03-11
期刊：
影响因子：
16.2
通讯作者：
Polley, Daniel B.
中科院分区：
文献类型：
--
作者：
Popescu, Maria V.;Polley, Daniel B.
在发育的关键时期，感官体验的退化会对大脑功能产生不利影响。在听觉系统中，与儿童耳部感染相关的传导性听力损失会产生长期的听觉感知敏锐度缺陷，就像视觉系统中的弱视一样。在这里，我们探索的神经机制，可能是基础上的“amblyaudio”通过诱导可逆的单耳剥夺（MD）在婴儿，少年和成年大鼠。MD使音调分布图失真，削弱了剥夺耳的表征，加强了开放耳的表征，破坏了双耳间水平差（ILD）的整合。双向可塑性效应受关键期的严格控制，在初级听觉皮层比下丘表达更强，并直接影响神经编码的准确性。这些研究结果突出了听觉表征之间的竞争可塑性的显着程度，并建议儿童听力损失的持久的知觉后遗症可能追溯到适应不良的可塑性在听觉皮层发育的关键时期。
Degraded sensory experience during critical periods of development can have adverse effects on brain function. In the auditory system, conductive hearing loss associated with childhood ear infections can produce long-lasting deficits in auditory perceptual acuity, much like amblyopia in the visual system. Here we explore the neural mechanisms that may underlie “amblyaudio” by inducing reversible monaural deprivation (MD) in infant, juvenile and adult rats. MD distorted tonotopic maps, weakened the deprived ear’s representation, strengthened the open ear’s representation and disrupted binaural integration of interaural level differences (ILD). Bidirectional plasticity effects were strictly governed by critical periods, were more strongly expressed in primary auditory cortex than inferior colliculus, and directly impacted neural coding accuracy. These findings highlight a remarkable degree of competitive plasticity between aural representations and suggest that the enduring perceptual sequelae of childhood hearing loss might be traced to maladaptive plasticity during critical periods of auditory cortex development.
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影响因子：
9.8
作者：
Kacelnik O;Nodal FR;Parsons CH;King AJ
通讯作者：
King AJ
影响因子：
3.4
作者：
Glazewski, S;McKenna, M;Fox, K
通讯作者：
Fox, K
影响因子：
2.5
作者：
Green, JS;Sanes, DH
通讯作者：
Sanes, DH
DOI：
10.1080/010503901750069572
发表时间：
2001-01-01
期刊：
SCANDINAVIAN AUDIOLOGY
影响因子：
--
作者：
Davis-Gunter, MJ;Löwenheim, H;Moore, EJ
通讯作者：
Moore, EJ
影响因子：
25
作者：
Bajo VM;Nodal FR;Moore DR;King AJ
通讯作者：
King AJ