Environmental noise affects auditory temporal processing development and NMDA-2B receptor expression in auditory cortex.
Environmental noise affects auditory temporal processing development and NMDA-2B receptor expression in auditory cortex.
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DOI：
10.1016/j.bbr.2010.11.028
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发表时间：
2011-03-17
影响因子：
2.7
通讯作者：
Allman, Brian L.
中科院分区：
文献类型：
--
作者：
Sun, Wei;Tang, Li;Allman, Brian L.
听觉时间加工是语音识别和言语理解的基础。在正常发育条件下，时间加工敏锐度随着年龄的增长而提高。最近的动物研究表明，听觉皮层（AC）的功能发育因早年暴露于环境噪声而受损（即，连续的、中等水平的、白色噪声），在此我们研究了时间处理敏锐度的正常年龄相关的改善是否对AC的延迟发展敏感。我们使用的行为范例，间隙诱导的前脉冲抑制的声惊吓反射，以评估差距检测阈值，并提供了一个比较的时间处理敏锐度之间的环境噪声饲养的大鼠和年龄匹配的控制。此外，由于年龄相关的变化通常发生在不同的N-甲基-D-天冬氨酸（NMDA）受体亚基的相对表达，我们评估的NMDA-2A和2B受体（NR 2A和NR 2B分别）的蛋白表达水平在AC环境噪声饲养后。正如假设的那样，在环境噪声中饲养的大鼠显示出1）成年时的时间处理敏锐度差（即，缺口检测阈值保持在幼年样水平升高），和2）与年龄匹配的对照相比，NR 2B蛋白表达水平增加。这种差的时间处理敏锐度代表延迟的发展，而不是永久性的损害，因为移动这些环境噪声饲养的大鼠到正常的声学条件下，提高了他们的差距检测阈值到一个年龄适当的水平。此外，住房正常饲养，成年大鼠在环境噪音两个月没有影响他们已经成熟的差距检测阈值。因此，在生命早期而不是成年期用环境噪声掩蔽正常声音输入损害了用差距检测阈值评估的时间处理敏锐度。
Auditory temporal processing is essential for sound discrimination and speech comprehension. Under normal developmental conditions, temporal processing acuity improves with age. As recent animal studies have shown that the functional development of the auditory cortex (AC) is impaired by early life exposure to environmental noise (i.e., continuous, moderate-level, white noise), here we investigated whether the normal age-related improvement in temporal processing acuity is sensitive to delayed development of the AC. We used a behavioral paradigm, the gap-induced prepulse inhibition of the acoustic startle reflex, to assess the gap detection threshold, and provide a comparison of temporal processing acuity between environmental noise-reared rats and age-matched controls. Moreover, because age-related changes normally occur in the relative expression of different N-methyl-D-aspartate (NMDA) receptor subunits, we assessed the level of protein expression of NMDA-2A and 2B receptors (NR2A and NR2B respectively) in the AC after environmental noise-rearing. As hypothesized, rats reared in environmental noise showed 1) poor temporal processing acuity as adults (i.e., gap detection threshold remained elevated at a juvenile-like level), and 2) an increased level of NR2B protein expression compared to age-matched controls. This poor temporal processing acuity represented delayed development rather than permanent impairment, as moving these environmental noise-reared rats to normal acoustic conditions improved their gap detection threshold to an age-appropriate level. Furthermore, housing normally-reared, adult rats in environmental noise for two months did not affect their already-mature gap detection threshold. Thus, masking normal sound inputs with environmental noise during early life, but not adulthood, impairs temporal processing acuity as assessed with the gap detection threshold.
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影响因子：
1.9
作者：
ISON, JR;OCONNOR, K;BOCIRNEA, A
通讯作者：
BOCIRNEA, A
影响因子：
3.7
作者：
Xu, Jinghong;Yu, Liping;Sun, Xinde
通讯作者：
Sun, Xinde
DOI：
10.1016/j.devbrainres.2004.06.003
发表时间：
2004-09-17
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Peiffer, AM;Friedman, JT;Fitch, RH
通讯作者：
Fitch, RH
DOI：
10.1044/jshr.3906.1315
发表时间：
1996-12-01
期刊：
JOURNAL OF SPEECH AND HEARING RESEARCH
影响因子：
--
作者：
Trehub, SE;Henderson, JL
通讯作者：
Henderson, JL
影响因子：
2.4
作者：
TREHUB, SE;SCHNEIDER, BA;HENDERSON, JL
通讯作者：
HENDERSON, JL