Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine.
Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine.
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DOI：
10.3390/pharmaceutics13060792
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发表时间：
2021-05-26
期刊：
影响因子：
5.4
通讯作者：
Romero G
中科院分区：
文献类型：
--
作者：
Muzzio N;Moya S;Romero G
随着人口老龄化以及由于先天性缺陷、创伤和疾病造成的组织和器官损失，对器官替代的需求不断增加，导致组织工程和再生医学（TERM）的新方法迅速发展。细胞外基质（ECM）是组织和器官中的重要组成部分，其围绕细胞并充当细胞的物理环境。因此，ECM已成为$TERM中支架和生物材料设计和制造的模型指南。然而，组织/器官替代物的制造或其再生是一个非常复杂的过程，并且通常需要几种策略的组合，例如开发具有多个功能的支架以及同时递送生长因子、生化信号、细胞、基因、免疫调节剂和外部刺激。虽然多功能支架和生物材料的发展是研究最多的方法之一，为$TERM，所有这些策略可以结合起来，其中开发新的协同方法，为组织再生。在这篇综述中，我们讨论了最近的进展，其中多功能支架单独或与其他策略相结合已被用于TERM的目的。
The increasing demand for organ replacements in a growing world with an aging population as well as the loss of tissues and organs due to congenital defects, trauma and diseases has resulted in rapidly evolving new approaches for tissue engineering and regenerative medicine (TERM). The extracellular matrix (ECM) is a crucial component in tissues and organs that surrounds and acts as a physical environment for cells. Thus, ECM has become a model guide for the design and fabrication of scaffolds and biomaterials in TERM. However, the fabrication of a tissue/organ replacement or its regeneration is a very complex process and often requires the combination of several strategies such as the development of scaffolds with multiple functionalities and the simultaneous delivery of growth factors, biochemical signals, cells, genes, immunomodulatory agents, and external stimuli. Although the development of multifunctional scaffolds and biomaterials is one of the most studied approaches for TERM, all these strategies can be combined among them to develop novel synergistic approaches for tissue regeneration. In this review we discuss recent advances in which multifunctional scaffolds alone or combined with other strategies have been employed for TERM purposes.
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