The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss.
The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss.
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DOI：
10.1136/bjophthalmol-2012-301525
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Argus II Study Group
中科院分区：
文献类型：
--
作者：
da Cruz L;Coley BF;Dorn J;Merlini F;Filley E;Christopher P;Chen FK;Wuyyuru V;Sahel J;Stanga P;Humayun M;Greenberg RJ;Dagnelie G;Argus II Study Group
视网膜假体系统（RPS）是一种新型的治疗外视网膜营养不良的深度视力丧失。理想的修复体将以适合日常生活的便携形式提供稳定、长期的视网膜刺激和可再现的空间分辨率。我们报告了Argus II系统的前瞻性、内部对照、多中心试验。28名具有光感视觉的受试者接受了视网膜植入。控制，封闭组，强迫选择字母识别，和，开放选择两个，三个和四个字母的单词识别测试进行。21名受试者的平均±SD字母正确识别率为：字母L、T、E、J、F、H、I、U，72.3±24.6%系统打开，17.7±12.9%系统关闭;字母A、Z、Q、V、N、W、O、C、D、M，55.0±27.4%系统开启和11.8%±10.7%系统关闭，字母K、R、G、X、B、Y、S、P，51.7±28.9%系统开启和15.3±7.4%系统关闭。（对于所有组，p<0.001）。一个由6名受试者组成的小组能够始终如一地阅读缩小尺寸的字母，最小尺寸为30厘米（1.7°），4名受试者正确识别未经排练的两个，三个和四个字母的单词。 平均植入时间为19.9个月。 配备Argus II系统的多名盲受试者使用该设备一致地识别字母和单词，这表明空间分辨率可重现。这与稳定的长期功能相结合，代表了人工视力发展的重大进展。
Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life. We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out. The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months. Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.
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影响因子：
2.6
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Zrenner, E
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