Tungsten disulfide nanotubes reinforced biodegradable polymers for bone tissue engineering.
Tungsten disulfide nanotubes reinforced biodegradable polymers for bone tissue engineering.
复制标题
钨二硫化物纳米管增强可生物降解的聚合物，用于骨组织工程。
DOI：
10.1016/j.actbio.2013.05.018
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发表时间：
2013-09
影响因子：
9.7
通讯作者：
Sitharaman, Balaji
中科院分区：
文献类型：
--
作者：
Lalwani, Gaurav;Henslee, Allan M.;Farshid, Behzad;Parmar, Priyanka;Lin, Liangjun;Qin, Yi-Xian;Kasper, F. Kurtis;Mikos, Antonios G.;Sitharaman, Balaji
关键词：
在这项研究中，我们已经调查了无机纳米管作为增强剂的功效，以提高聚（富马酸丙二醇酯）（PPF）复合材料的力学性能作为纳米材料加载浓度（0.01-0.2重量%）的函数。实验组中使用二硫化钨纳米管（WSNTs）作为增强剂。单壁和多壁碳纳米管（SWCNT和MWCNT）用作阳性对照，交联的PPF复合材料用作基线对照。机械测试（压缩和三点弯曲）显示与基线对照相比，WSNT增强的PPF纳米复合材料的机械性能（压缩模量、压缩屈服强度、弯曲模量和弯曲屈服强度）显著增强（高达28-190%）。与阳性对照相比，在各种浓度下，还观察到WSNT纳米复合材料的机械性能的显著改善。一般来说，无机纳米管（WSNTs）表现出更好的（高达127%）或等效的机械增强相比，碳纳米管（SWCNT和MWCNT）。溶胶分数分析表明，在WSNTs（0.01-0.2重量%）的存在下，PPF的交联密度显着增加。透射电子显微镜（TEM）分析的薄切片的交联纳米复合材料显示存在的WSNTs作为单独的纳米管在PPF矩阵，而单壁碳纳米管和多壁碳纳米管存在的微米级的聚集体。通过BET表面积分析获得的纳米结构的表面积的趋势是SWCNTs > MWCNTs > WSNTs。BET表面积分析、TEM分析和溶胶分数分析结果一起表明，（无机与碳纳米材料），官能团的存在（例如硫化物和氧硫化物），以及纳米材料在聚合物基质中的单独分散（增强剂不存在聚集）是影响纳米结构增强PPF复合材料的机械性能的关键参数，以及与基线和阳性对照相比观察到的机械性能增加的原因。
In this study, we have investigated the efficacy of inorganic nanotubes as reinforcing agents to improve the mechanical properties of poly(propylene fumarate) (PPF) composites as a function of nanomaterial loading concentration (0.01-0.2 wt%). Tungsten disulfide nanotubes (WSNTs) were used as reinforcing agents in the experimental groups. Single- and multi- walled carbon nanotubes (SWCNTs and MWCNTs) were used as positive controls, and crosslinked PPF composites were used as baseline control. Mechanical testing (compression and three-point bending) shows a significant enhancement (up to 28-190%) in the mechanical properties (compressive modulus, compressive yield strength, flexural modulus, and flexural yield strength) of WSNT reinforced PPF nanocomposites compared to the baseline control. In comparison to positive controls, at various concentrations, significant improvements in the mechanical properties of WSNT nanocomposites were also observed. In general, the inorganic nanotubes (WSNTs) showed a better (up to 127%) or equivalent mechanical reinforcement compared to carbon nanotubes (SWCNTs and MWCNTs). Sol fraction analysis showed significant increases in the crosslinking density of PPF in the presence of WSNTs (0.01-0.2 wt%). Transmission electron microscopy (TEM) analysis on thin sections of crosslinked nanocomposites showed the presence of WSNTs as individual nanotubes in the PPF matrix, whereas SWCNTs and MWCNTs existed as micron sized aggregates. The trend in the surface area of nanostructures obtained by BET surface area analysis was SWCNTs > MWCNTs > WSNTs. The BET surface area analysis, TEM analysis, and sol fraction analysis results taken together suggest that chemical composition (inorganic vs. carbon nanomaterials), presence of functional groups (such as sulfide and oxysulfide), and individual dispersion of the nanomaterials in the polymer matrix (absence of aggregation of the reinforcing agent) are the key parameters affecting the mechanical properties of nanostructure-reinforced PPF composites, and the reason for the observed increases in the mechanical properties compared to the baseline and positive controls.
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影响因子：
5.5
作者：
Mitchell, CA;Bahr, JL;Krishnamoorti, R
通讯作者：
Krishnamoorti, R
影响因子：
10.9
作者：
Lalwani, Gaurav;Kwaczala, Andrea Trinward;Kanakia, Shruti;Patel, Sunny C.;Judex, Stefan;Sitharaman, Balaji
通讯作者：
Sitharaman, Balaji
影响因子：
4.3
作者：
Dyke, CA;Tour, JM
通讯作者：
Tour, JM
影响因子：
2.4
作者：
RHO, JY;ASHMAN, RB;TURNER, CH
通讯作者：
TURNER, CH
影响因子：
3.5
作者：
Shi, XF;Hudson, JL;Mikos, AG
通讯作者：
Mikos, AG