Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation.

Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation.
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DOI:
10.1039/c5cs00793c
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发表时间:
2016-04-21
影响因子:
46.2
通讯作者:
Cronin L
Cronin L
中科院分区:
化学1区
文献类型:
--
作者:
Sans V;Cronin L

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在研究和工业环境中,连续流平台在合成化学中的应用越来越普遍。在线集成分析能够实时获得有关反应进程、催化活性和稳定性等的大量信息。此外,还可以通过手动或自动反馈优化来影响反应进程和选择性,从而构成采用数字合成的dial-a-molecule方法。本文概述了迄今为止该领域最重要的贡献。
The employment of continuous-flow platforms for synthetic chemistry is becoming increasingly popular in research and industrial environments. Integrating analytics in-line enables obtaining a large amount of information in real-time about the reaction progress, catalytic activity and stability, etc. Furthermore, it is possible to influence the reaction progress and selectivity via manual or automated feedback optimisation, thus constituting a dial-a-molecule approach employing digital synthesis. This contribution gives an overview of the most significant contributions in the field to date.
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