Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model.
Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model.
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DOI：
10.1111/jon.12996
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发表时间：
2022-07
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影响因子：
--
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中科院分区：
文献类型：
--
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阿尔茨海默病（AD）中大脑的生物力学变化尚未完全阐明。我们旨在研究β-淀粉样蛋白积累对小鼠脑粘弹性的影响。采用磁共振弹性成像技术计算了9只转基因J20 （AD）小鼠（5公4母）和10只野生型C57BL/6小鼠（5公5母）在11月龄和14月龄时全脑组织（WB）和双侧海马的粘弹性模量（|G*|）、弹性（Gd）和粘度（Gl）。横断面分析显示，在任何时间点AD和WT小鼠之间均无显著差异。在11月龄时，没有观察到性别特异性差异，但在14月龄时，AD女性的海马|G*|和Gl以及WB |G*|， Gd和Gl均明显高于AD和WT男性。雌性AD动物与雌性WT动物之间存在相似的趋势差异，但没有达到显著性。纵向分析显示，AD和WT小鼠在11 - 14个月期间海马|G*|、Gd和Gl显著增加，WB |G*|、Gd和Gl显著降低。每个亚组的所有海马测量值均显著升高，所有WB测量值均显著降低，但AD女性的WB |G*|、Gd或Gl没有显著变化。衰老对脑粘弹性有区域特异性影响，即WB软化和海马硬化。淀粉样斑块沉积可能有性别特异性的影响，这需要进一步的研究。
Biomechanical changes in the brain have not been fully elucidated in Alzheimer’s disease (AD). We aimed to investigate the effect of β-amyloid accumulation on mouse brain viscoelasticity. Magnetic Resonance Elastography was used to calculate magnitude of the viscoelastic modulus (|G*|), elasticity (Gd), and viscosity (Gl) in the whole brain parenchyma (WB) and bilateral hippocampi of 9 transgenic J20 (AD) mice (5 males/4 females) and 10 wild-type (WT) C57BL/6 mice (5 males/5 females) at 11 and 14 months of age. Cross-sectional analyses showed no significant difference between AD and WT mice at either time-points. No sex-specific differences were observed at 11 months of age, but AD females showed significantly higher hippocampal |G*| and Gl and WB |G*|, Gd and Gl compared to both AD and WT males at 14 months of age. Similar trending differences were found between female AD and female WT animals but did not reach significance. Longitudinal analyses showed significant increases in hippocampal |G*|, Gd, and Gl, and significant decreases in WB |G*|, Gd, and Gl between 11 and 14 months in both AD and WT mice. Each subgroup showed significant increases in all hippocampal and significant decreases in all WB measures, with the exception of AD females, which showed no significant changes in WB |G*|, Gd, or Gl. Aging had region-specific effects on cerebral viscoelasticity, namely WB softening and hippocampal stiffening. Amyloid plaque deposition may have sex-specific effects, which require further scrutiny.
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影响因子：
5.7
作者：
Murphy MC;Huston J 3rd;Ehman RL
通讯作者：
Ehman RL
影响因子：
4.2
作者：
Hiscox LV;Johnson CL;McGarry MDJ;Perrins M;Littlejohn A;van Beek EJR;Roberts N;Starr JM
通讯作者：
Starr JM
整个阿尔茨海默氏病谱系中的区域大脑僵硬变化。
DOI：
10.1016/j.nicl.2015.12.007
发表时间：
2016
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Murphy MC;Jones DT;Jack CR Jr;Glaser KJ;Senjem ML;Manduca A;Felmlee JP;Carter RE;Ehman RL;Huston J 3rd
通讯作者：
Huston J 3rd
通过磁共振弹性成像确定阿尔茨海默氏病的大脑硬度降低。
影响因子：
4.4
作者：
Murphy, Matthew C.;Huston, John, III;Jack, Clifford R., Jr.;Glaser, Kevin J.;Manduca, Armando;Felmlee, Joel P.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
5
作者：
ElSheikh, Mona;Arani, Arvin;Huston, John, III
通讯作者：
Huston, John, III