The mediating role of cortical thickness and gray matter volume on sleep slow-wave activity during adolescence.
The mediating role of cortical thickness and gray matter volume on sleep slow-wave activity during adolescence.
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DOI：
10.1007/s00429-017-1509-9
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发表时间：
2018-03
影响因子：
3.1
通讯作者：
Baker FC
中科院分区：
文献类型：
--
作者：
Goldstone A;Willoughby AR;de Zambotti M;Franzen PL;Kwon D;Pohl KM;Pfefferbaum A;Sullivan EV;Müller-Oehring EM;Prouty DE;Hasler BP;Clark DB;Colrain IM;Baker FC
在青春期期间，皮质厚度和灰质 (GM) 体积会减少，睡眠期间的慢波 (δ) 活动 (SWA) 会减少 65%，但缺乏将这些结构性大脑和功能性睡眠差异联系起来的经验数据。在这里，我们专门研究了皮质厚度和 GM 体积和皮质厚度与年龄相关的差异是否解释了睡眠期间慢波 (delta) 活动 (SWA) 的典型年龄相关差异。来自国家青少年酒精与神经发育联盟 (NCANDA) 研究的 132 名健康参与者（年龄：12-21 岁）参与了基线多导睡眠图、脑电图 (EEG) 和磁共振成像 (MRI) 数据的横断面分析。通过应用中介模型，我们发现年龄对青少年的 SWA 有很大的直接影响，这解释了 45% 的 ultra-SWA（0.3 至 1Hz）方差和 52% 的 delta-SWA（1Hz 至 <4Hz）方差，其中年龄较大的青少年的 SWA 较低，如先前报道的那样。此外，我们提供的证据表明，几个主要是额叶和顶叶的大脑区域的结构部分介导了这种直接年龄效应，包括大脑结构测量的模型解释了 ultra-SWA 中额外 3-9% 的方差和 delta-SWA 中 4-5% 的方差，性别之间没有差异。在模型中用青春期状态代替年龄产生了类似的结果。由于 GM 体积和皮质厚度的减少可能表明突触修剪和髓鞘形成，这些结果表明，年龄较大、更成熟的青少年中 SWA 的减少可能很大程度上是由许多额叶和顶叶大脑区域内的此类过程驱动的。
During the course of adolescence, reductions occur in cortical thickness and gray matter (GM) volume, along with a 65% reduction in slow wave (delta) activity during sleep (SWA) but empirical data linking these structural brain and functional sleep differences, is lacking. Here we investigated specifically whether age-related differences in cortical thickness and GM volume and cortical thickness accounted for the typical age-related difference in slow wave (delta) activity (SWA) during sleep. 132 healthy participants (age: 12–21 years) from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) study were included in this cross-sectional analysis of baseline polysomnographic, electroencephalographic (EEG) and magnetic resonance imaging (MRI) data. By applying mediation models we identified a large, direct effect of age on SWA in adolescents, which explained 45% of the variance in ultra-SWA (0.3 to 1Hz) and 52% of the variance in delta-SWA (1Hz to <4Hz), where SWA was lower in older adolescents, as has been reported previously. In addition, we provide evidence that the structure of several, predominantly frontal and parietal brain regions, partially mediated this direct age effect, Models including measures of brain structure explained an additional 3–9% of the variance in ultra-SWA and 4–5% of the variance in delta-SWA, with no differences between sexes. Replacing age with pubertal status in models produced similar results. As reductions in GM volume and cortical thickness likely indicate synaptic pruning and myelination, these results suggest that diminished SWA in older, more mature adolescents may largely be driven by such processes within a number of frontal and parietal brain regions.
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影响因子：
3.7
作者：
Bramen JE;Hranilovich JA;Dahl RE;Chen J;Rosso C;Forbes EE;Dinov ID;Worthman CM;Sowell ER
通讯作者：
Sowell ER
影响因子：
3.7
作者：
Bramen, Jennifer E.;Hranilovich, Jennifer A.;Sowell, Elizabeth R.
通讯作者：
Sowell, Elizabeth R.
影响因子：
4.7
作者：
Benoit, O;Daurat, A;Prado, J
通讯作者：
Prado, J
影响因子：
3.3
作者：
Achermann, P;Borbely, AA
通讯作者：
Borbely, AA
DOI：
10.1073/pnas.1120860109
发表时间：
2012-04-10
影响因子：
11.1
作者：
Campbell, Ian G.;Grimm, Kevin J.;Feinberg, Irwin
通讯作者：
Feinberg, Irwin