Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies.
Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies.
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DOI：
10.3988/jcn.2019.15.1.9
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Fei X
中科院分区：
文献类型：
--
作者：
He Q;Chen X;Wu T;Li L;Fei X
关于苯二氮卓类药物（BDZ）与痴呆风险之间的相关性，文献中存在相互矛盾的证据。这项荟萃分析旨在确定长期使用BDZ与痴呆风险之间的关系。系统检索了截至2017年9月的PubMed和Embase数据库中的相关出版物。文献检索的重点是分析长期使用BDZ与痴呆风险之间关系的观察性研究。使用随机效应模型评估合并率比（RR）和95%置信区间（CI）。通过进行亚组和敏感性分析检查结果的稳健性。纳入了10项研究：6项病例对照研究和4项队列研究。在服用BDZ的患者中，发生痴呆的合并RR为1.51（95% CI=1.17-1.95，p=0.002）。服用半衰期较长（RR=1.16，95% CI=0.95-1.41，p=0.150）和时间较长（RR=1.21，95% CI=1.04-1.40，p=0.016）BDZ的患者痴呆风险较高。这项荟萃分析汇集了10项研究，表明BDZ显著增加老年人群患痴呆症的风险。在服用BDZ的患者中，半衰期较长（>20小时）和持续时间较长（>3年）的风险较高。
There is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the long-term usage of BDZs and the risk of dementia. The PubMed and Embase databases were systematically searched for relevant publications up to September 2017. The literature search focused on observational studies that analyzed the relationship between the long-term use of BDZs and the risk of dementia. Pooled rate ratios (RRs) with 95% confidence interval (CI) were assessed using a random-effects model. The robustness of the results was checked by performing subgroup and sensitivity analyses. Ten studies were included: six case–control and four cohort studies. The pooled RR for developing dementia was 1.51 (95% CI=1.17–1.95, p=0.002) in patients taking BDZ. The risk of dementia was higher in patients taking BDZs with a longer half-life (RR=1.16, 95% CI=0.95–1.41, p=0.150) and for a longer time (RR=1.21, 95% CI=1.04–1.40, p=0.016). This meta-analysis that pooled ten studies has shown that BDZ significantly increases the risk of dementia in the elderly population. The risk is higher in patients taking BDZ with a longer half-life (>20 hours) and for a longer duration (>3 years).
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DOI：
10.4088/jcp.08m04181
发表时间：
2009-04
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Taragano FE;Allegri RF;Krupitzki H;Sarasola DR;Serrano CM;Loñ L;Lyketsos CG
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DOI：
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发表时间：
2014-09-09
期刊：
BMJ (Clinical research ed.)
影响因子：
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作者：
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影响因子：
14
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影响因子：
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影响因子：
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作者：
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通讯作者：
ROBISON, PM