Age-related neuronal loss in the rat brain starts at the end of adolescence.
Age-related neuronal loss in the rat brain starts at the end of adolescence.
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DOI：
10.3389/fnana.2012.00045
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发表时间：
2012
影响因子：
2.9
通讯作者：
Herculano-Houzel S
中科院分区：
文献类型：
--
作者：
Morterá P;Herculano-Houzel S
大脑中与衰老有关的变化主要通过比较年轻的成年动物和非常老的动物来研究。然而，衰老必须被认为是一个终生的累积变化过程，最终在老年时变得明显。为了确定这种衰退过程何时开始，我们研究了大鼠大脑的细胞组成从婴儿期到青春期、成年早期和老年的变化。使用各向同性分馏器来确定不同脑区域中神经元和非神经元细胞的总数，我们发现神经元数量的主要增加发生在青春期，在1和2-3个月之间，随后是早在3个月大时开始的广泛和进行性神经元损失的显著趋势，此时神经元数量在所有结构中最大，直到12或22个月大时神经元数量明显减少。我们的研究结果表明，与年龄相关的大脑衰退在青春期结束时就开始了，这一新发现对公共卫生和福利具有重要的临床和社会意义。
Aging-related changes in the brain have been mostly studied through the comparison of young adult and very old animals. However, aging must be considered a lifelong process of cumulative changes that ultimately become evident at old age. To determine when this process of decline begins, we studied how the cellular composition of the rat brain changes from infancy to adolescence, early adulthood, and old age. Using the isotropic fractionator to determine total numbers of neuronal and non-neuronal cells in different brain areas, we find that a major increase in number of neurons occurs during adolescence, between 1 and 2–3 months of age, followed by a significant trend of widespread and progressive neuronal loss that begins as early as 3 months of age, when neuronal numbers are maximal in all structures, until decreases in numbers of neurons become evident at 12 or 22 months of age. Our findings indicate that age-related decline in the brain begins as soon as the end of adolescence, a novel finding has important clinical and social implications for public health and welfare.
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影响因子：
4.2
作者：
ADAMS, I;JONES, DG
通讯作者：
JONES, DG
影响因子：
--
作者：
GEINISMAN, Y;BONDAREFF, W;DODGE, JT
通讯作者：
DODGE, JT
影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
2.5
作者：
Cannon, Jason R.;Greenamyre, J. Timothy
通讯作者：
Greenamyre, J. Timothy
影响因子：
3.3
作者：
BARJA, G;CADENAS, S;LOPEZTORRES, M
通讯作者：
LOPEZTORRES, M