Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain.
Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain.
复制标题
用抗体中和Hv 1/HVCN 1通过促进它们在脑中的迁移来增强小胶质细胞/大胶质细胞髓鞘清除。
DOI：
10.3389/fncel.2021.768059
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发表时间：
2021
影响因子：
5.3
通讯作者：
Zhao JW
中科院分区：
文献类型：
--
作者：
Wang F;Ma XR;Wu Y;Xu YC;Gu HM;Wang DX;Dong ZJ;Li HL;Wang LB;Zhao JW
Microglia dynamically monitor the microenvironment of the central nervous system (CNS) by constantly extending and retracting their processes in physiological conditions, and microglia/macrophages rapidly migrate into lesion sites in response to injuries or diseases in the CNS. Consequently, their migration ability is fundamentally important for their proper functioning. However, the mechanisms underlying their migration have not been fully understood. We wonder whether the voltage-gated proton channel HVCN1 in microglia/macrophages in the brain plays a role in their migration. We show in this study that in physiological conditions, microglia and bone marrow derived macrophage (BMDM) express HVCN1 with the highest level among glial cells, and upregulation of HVCN1 in microglia/macrophages is presented in multiple injuries and diseases of the CNS, reflecting the overactivation of HVCN1. In parallel, myelin debris accumulation occurs in both the focal lesion and the site where neurodegeneration takes place. Importantly, both genetic deletion of the HVCN1 gene in cells in vitro and neutralization of HVCN1 with antibody in the brain in vivo promotes migration of microglia/macrophages. Furthermore, neutralization of HVCN1 with antibody in the brain in vivo promotes myelin debris clearance by microglia/macrophages. This study uncovers a new role of HVCN1 in microglia/macrophages, coupling the proton channel HVCN1 to the migration of microglia/macrophages for the first time.
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影响因子：
5.1
作者：
Fu, Ruying;Shen, Qingyu;Xu, Pengfei;Luo, Jin Jun;Tang, Yamei
通讯作者：
Tang, Yamei
影响因子：
4.8
作者：
García-Fernández P;Üçeyler N;Sommer C
通讯作者：
Sommer C
影响因子：
15.9
作者：
Kreutzberg, GW
通讯作者：
Kreutzberg, GW
影响因子：
2.9
作者：
DeCoursey TE
通讯作者：
DeCoursey TE
小胶质细胞 Hv1 加剧小鼠脊髓损伤后的继发性损伤
DOI：
10.1016/j.bbrc.2020.02.012
发表时间：
2020-04-23
影响因子：
3.1
作者：
Li, Xuefei;Liu, Rui;Luo, Xiang
通讯作者：
Luo, Xiang