Controlled comparison of electrophysiological sleep in families of probands with unipolar depression.
Controlled comparison of electrophysiological sleep in families of probands with unipolar depression.
复制标题
单相抑郁先证者家族电生理睡眠的对照比较。
DOI：
10.1176/ajp.155.2.192
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Roffwarg,HP
中科院分区：
文献类型：
--
作者：
Giles,DE;Kupfer,DJ;Rush,AJ;Roffwarg,HP
本研究提供了单相抑郁症和短REM潜伏期的先证者的父母和兄弟姐妹，单相抑郁症和正常REM潜伏期的先证者的多导睡眠图数据和精神病史，方法先证者（N=64）的父母和成年兄弟姐妹（N=252）研究对象在睡眠实验室进行3个晚上的精神疾病史的评估，其中，睡眠-快速眼动睡眠潜伏期预测了精神疾病的终生史抑郁症的症状。短REM潜伏期也与慢波睡眠缺陷有关。REM潜伏期短的抑郁先证者的亲属中REM潜伏期短的比率是REM潜伏期正常的抑郁先证者和正常先证者的亲属中REM潜伏期正常的比率的四倍。抑郁症的终生风险几乎是两倍高的亲属抑郁症先证者短REM潜伏期的亲属抑郁症先证者正常REM latent.CONCLUSIONSShort REM潜伏期和慢波睡眠缺陷是家族性的。短REM潜伏期与抑郁症的风险增加相关，超过与抑郁症先证者相关的家族风险。多导睡眠图异常也发生在未受影响的亲属。虽然这些数据只能被认为是提示性的，但这些发现表明，多导睡眠图异常可能先于抑郁症的临床表现，并可能有助于识别那些最高风险的疾病。(Am精神病学杂志1998; 155：192-199）
OBJECTIVEThis study presents polysomnographic data and psychiatric history for parents and siblings of probands with unipolar depression and short REM latency, probands with unipolar depression and normal REM latency, and normal comparison probands.METHODParents and adult siblings (N=252) of probands (N=64) were evaluated for lifetime history of psychiatric disorders and were studied in the sleep laboratory for 3 nights.RESULTSREM latency predicted lifetime history of major depression. Short REM latency was also associated with slow wave sleep deficits. Rate of short REM latency in relatives of depressed probands with short REM latency quadrupled the rate in relatives of both depressed probands with normal REM latency and normal probands. Lifetime risk of depression was almost twice as high in relatives of depressed probands with short REM latency as in relatives of depressed probands with normal REM latency.CONCLUSIONSShort REM latency and slow wave sleep deficits are familial. Short REM latency is associated with increased risk of major depression beyond the familial risk associated with a depressed proband. Polysomnographic abnormalities also occurred in unaffected relatives. Although the data can be considered only suggestive, these findings indicate that polysomnographic abnormalities may precede the clinical expression of depression and may be useful in identifying those at highest risk for the illness. (Am J Psychiatry 1998; 155:192–199)
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