New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies.
New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies.
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抗CD4(+)T淋巴细胞抗体诱导肺孢子虫肺炎新大鼠模型。
DOI：
10.1128/iai.71.11.6292-6297.2003
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发表时间：
2003
影响因子：
3.1
通讯作者：
Walzer,PeterD
中科院分区：
文献类型：
--
作者：
Thullen,TimothyD;Ashbaugh,AlanD;Daly,KieranR;Linke,MichaelJ;Steele,PaulE;Walzer,PeterD
CD 4 +T淋巴细胞在宿主防御肺孢子虫病中起着核心作用，但在大鼠中仅受到有限的关注。对接触肺孢子虫的刘易斯大鼠给予CD 4 + T细胞耗竭（OX-38）和非耗竭（W3/25）单克隆抗体长达14周，这些抗体识别相同或相邻的表位。虽然OX-38比W3/25产生更大的循环CD 4+细胞减少，但两种抗体治疗对大鼠健康和肺孢子虫病水平的影响相似，比皮质类固醇的影响更轻。W3/25也没有增加单纯皮质类固醇治疗的肺孢子虫病的严重程度。我们的结论是，CD 4+细胞功能是更重要的比CD 4+细胞数量在宿主防御againstPneumocystisin大鼠，这种新的模型允许研究机会性感染的大鼠没有皮质类固醇的混杂作用。
The CD4+T lymphocyte plays a central role in host defense againstPneumocystispneumonia but has received only limited attention in rats. CD4+T-cell-depleting (OX-38) and nondepleting (W3/25) monoclonal antibodies, which recognize an identical or adjacent epitope, were administered for up to 14 weeks to Lewis rats that had been exposed toPneumocystis. While OX-38 produced a greater decrease in circulating CD4+cells than W3/25, both antibody treatments resulted in similar effects on the health of the rats and the levels ofPneumocystispneumonia, which were milder than those found with corticosteroids. W3/25 also did not enhance the severity ofPneumocystispneumonia achieved with corticosteroids alone. We conclude that CD4+cell function is more important than CD4+cell number in host defense againstPneumocystisin the rat and that this new model permits study of opportunistic infections in the rat without the confounding effects of corticosteroids.
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DOI：
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发表时间：
1983
期刊：
Journal of molecular and applied genetics
影响因子：
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作者：
N. Heisterkamp;J. Groffen;J. Stephenson
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DOI：
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发表时间：
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期刊：
The Lancet
影响因子：
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作者：
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作者：
ROWLEY, JD
通讯作者：
ROWLEY, JD