A plant-unique protein BLISTER coordinates with core retromer to modulate endosomal sorting of plasma membrane and vacuolar proteins.
A plant-unique protein BLISTER coordinates with core retromer to modulate endosomal sorting of plasma membrane and vacuolar proteins.
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植物独特的蛋白质 BLISTER 与核心逆转录酶协调调节质膜和液泡蛋白的内体分选
DOI:
10.1073/pnas.2211258120
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发表时间:
2023-01-03
影响因子:
11.1
通讯作者:
中科院分区:
文献类型:
--
作者:
Significance As an important membrane remodeling machinery, the retromer binds to endosomes and regulates the trafficking of vacuolar storage proteins and the recycling of endocytosed proteins in plants. However, the factors involved in regulating the assembly and endosomal recruitment of the plant retromer core complex remain elusive. Here, we identified BLISTER (BLI) as a plant-unique endosomal regulator, which affects the assembly and membrane recruitment of the core retromer complex, thereby controlling the vacuolar transport of soluble vacuolar proteins and the recycling of endocytosed plasma membrane proteins. This study broadens our understandings of the mechanism underlying retromer regulation in plants and highlights the unique properties of the plant-specific protein BLI in modulating retromer-regulated endosomal trafficking.
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影响因子:
7.4
作者:
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通讯作者:
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