Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population.
Association between drinking-related antisocial behavior and a polymorphism in the serotonin transporter gene in a Japanese population.
复制标题
日本人群中饮酒相关的反社会行为与血清素转运蛋白基因多态性之间的关联。
DOI：
--
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
T. Arinami
中科院分区：
文献类型：
--
作者：
H. Ishiguro;Toshikazu Saito;S. Akazawa;H. Mitushio;Kunimaro Tada;M. Enomoto;H. Mifune;M. Toru;H. Shibuya;T. Arinami
背景
已有研究表明5-羟色胺能系统(S/S)参与了小鼠和人类的酒精中毒。既往研究表明，5-羟色胺转运体基因启动子多态性的S/S基因型与以严重戒断症状为特征的严重酒精依赖有关。它还与表现出反社会人格障碍的酗酒者有关。
方法
我们检测了166名经历戒断、癫痫或精神错乱的日本酗酒者和290名日本对照的基因多态性。
结果
S/S等位基因在患者中未见增加。探索性分析显示，在有饮酒相关逮捕史的酗酒者中，S等位基因和S/S基因型的频率明显低于对照组(分别为p=0.009和p=0.03)，这可能反映了先前报道的与S/S相关的伤害回避人格特征。携带L等位基因的酒鬼比携带S/S基因型的酗酒者出现酒依赖的时间明显提前(p=0.01)。
结论
本研究未能为S/S基因与日本人中以躯体戒断症状或反社会行为为特征的严重酒精中毒之间的关联提供支持性证据。尽管我们的数据支持中枢5-羟色胺能系统参与某些类型的酒精中毒，但这项研究的潜在关联发现只是探索性的，因此，在其他研究重复之前，应该被理解为试验性的。
BACKGROUND
Involvement of the serotoninergic system (S/S) in alcoholism has been suggested in both mice and humans. Previous studies have suggested the S/S genotype of the serotonin transporter gene promoter polymorphism to be associated with severe alcohol dependence marked by severe withdrawal symptoms. It has also been associated with alcoholics who exhibit a dissocial personality disorder.
METHODS
We examined the polymorphism in 166 Japanese alcoholics who experienced withdrawal seizure or delirium and 290 Japanese controls.
RESULTS
The S/S genotype was not increased in the patients. Exploratory analyses showed significantly less frequent S allele and S/S genotype frequencies in the alcoholics with a history of drinking-related arrests than in the controls (p = 0.009 and p = 0.03, respectively), perhaps reflecting previously reported harm avoidance personality traits associated with S/S. Alcoholics with the L allele had a significantly earlier onset of alcohol dependence than those with the S/S genotype (p = 0.01).
CONCLUSIONS
The present study failed to provide supportive evidence for an association of the S/S genotype with severe alcoholism marked by physical withdrawal symptoms or with antisocial behaviors among the Japanese. Although our data support involvement of the central serotoninergic system in some types of alcoholism, the potential association findings of this study emerged as only exploratory and, therefore, should be understood as tentative until replicated in other studies.
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影响因子：
56.9
作者：
CLONINGER, CR
通讯作者：
CLONINGER, CR
嗜酒大鼠前脑中的血清素免疫反应纤维减少。
DOI：
10.1111/j.1530-0277.1994.tb00912.x
发表时间：
1994
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Zhou,FC;Bledsoe,S;Lumeng,L;Li,TK
通讯作者：
Li,TK
抑郁症中血清素能神经元系统的神经化学改变。
DOI：
--
发表时间：
1992
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Risch,SC;Nemeroff,CB
通讯作者：
Nemeroff,CB
DOI：
10.1111/j.1530-0277.1998.tb03704.x
发表时间：
1998-08-01
影响因子：
3.2
作者：
Edenberg, HJ;Reynolds, J;Foroud, T
通讯作者：
Foroud, T