Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study.
Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study.
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客观睡眠时间短的失眠与 2 型糖尿病相关：一项基于人群的研究。
DOI：
10.2337/dc09-0284
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发表时间：
2009-11
期刊：
影响因子：
16.2
通讯作者：
Bixler EO
中科院分区：
文献类型：
--
作者：
Vgontzas AN;Liao D;Pejovic S;Calhoun S;Karataraki M;Bixler EO
我们研究了失眠和客观的短睡眠时间的联合作用，这两者的结合与较高的发病率有关，对糖尿病的风险。从宾夕法尼亚州中部随机挑选的1,741名男性和女性在睡眠实验室进行了研究。失眠定义为持续时间≥1年的失眠主诉，而睡眠不佳定义为入睡困难、保持睡眠或最终早醒的主诉。多导睡眠图睡眠持续时间分为三类：≥6小时睡眠（样本的前50%）; 5-6小时（样本的大约第三四分位数）; ≤5小时（样本的大约底部四分位数）。根据空腹血糖>126 mg/dl或使用药物来定义糖尿病。在逻辑回归模型中，我们同时调整了年龄、种族、性别、BMI、吸烟、饮酒、抑郁、睡眠呼吸障碍和周期性肢体运动。慢性失眠而不是睡眠不好与糖尿病的高风险有关。与睡眠正常且睡眠时间≥6 h组相比，失眠且睡眠时间≤5 h组患糖尿病的风险最高（比值比[95%CI] 2.95 [1.2-7.0]），睡眠时间5-6 h的失眠患者患糖尿病的风险最高（2.07 [0.68-6.4]）。睡眠时间短的失眠与糖尿病的几率增加有关。客观的睡眠时间可以预测慢性失眠症的心脏代谢发病率，其医学影响一直被低估。
We examined the joint effects of insomnia and objective short sleep duration, the combination of which is associated with higher morbidity, on diabetes risk. A total of 1,741 men and women randomly selected from Central Pennsylvania were studied in the sleep laboratory. Insomnia was defined by a complaint of insomnia with duration of ≥1 year, whereas poor sleep was defined as a complaint of difficulty falling asleep, staying asleep, or early final awakening. Polysomnographic sleep duration was classified into three categories: ≥6 h of sleep (top 50% of the sample); 5–6 h (approximately third quartile of the sample); and ≤5 h (approximately the bottom quartile of the sample). Diabetes was defined either based on a fasting blood glucose >126 mg/dl or use of medication. In the logistic regression model, we simultaneously adjusted for age, race, sex, BMI, smoking, alcohol use, depression, sleep-disordered breathing, and periodic limb movement. Chronic insomnia but not poor sleep was associated with a higher risk for diabetes. Compared with the normal sleeping and ≥6 h sleep duration group, the highest risk of diabetes was in individuals with insomnia and ≤5 h sleep duration group (odds ratio [95% CI] 2.95 [1.2–7.0]) and in insomniacs who slept 5–6 h (2.07 [0.68–6.4]). Insomnia with short sleep duration is associated with increased odds of diabetes. Objective sleep duration may predict cardiometabolic morbidity of chronic insomnia, the medical impact of which has been underestimated.
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影响因子：
8.2
作者：
Meisinger, C;Heier, M;Loewel, H
通讯作者：
Loewel, H
影响因子：
2.8
作者：
Basta, Maria;Chrousos, George P.;Vgontzas, Alexandros N.
通讯作者：
Vgontzas, Alexandros N.
影响因子：
5.6
作者：
BONNET, MH;ARAND, DL
通讯作者：
ARAND, DL
影响因子：
5
作者：
Punjabi, NM;Shahar, E;Resnick, HE
通讯作者：
Resnick, HE
影响因子：
3.3
作者：
Bonnet, MH;Arand, DL
通讯作者：
Arand, DL