Impact of multiple cardiovascular risk factors on carotid intima-media thickness and elasticity.
Impact of multiple cardiovascular risk factors on carotid intima-media thickness and elasticity.
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多种心血管危险因素对颈动脉内膜中层厚度和弹性的影响
DOI：
10.1371/journal.pone.0067809
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zheng H
中科院分区：
文献类型：
--
作者：
Niu L;Zhang Y;Qian M;Meng L;Xiao Y;Wang Y;Liu X;Zheng R;Zheng H
颈动脉内膜中层厚度（IMT）和弹性已被证明是心血管疾病（CVD）的独立预测因子。心血管危险因素（CVRF）包括高血压、血脂异常、糖尿病、超重和吸烟。目的是研究CVRF的三个或更多个组分的聚集是否比CVRF的单个组分对颈动脉IMT和弹性的影响更大。方法将173例无心血管疾病的受试者分为两组，即多次CVRF组（n = 55）和对照组（n = 118）。 分别采用B超和血管纹理匹配法（VTMM）测量颈动脉IMT和弹性模量。结果与对照组相比，多次CVRF可使颈动脉IMT（43%，p<0.0001）和弹性模量（60%，p<0.0001）不成比例增加。多元回归模型（包括年龄、性别以及CVRF的每个单独组分作为连续变量）显示，多个CVRF是IMT（p = 0.042）和弹性（p = 0.008）的独立决定因素。 在经年龄校正的方差分析中，与未发生CVRF的受试者相比，发生单次、两次和多次CVRF的受试者的IMT分别增加8.1%、42.2%和66%，弹性模量分别增加54.6%、94.3%和125.2%。结论多个CVRF的聚集性对颈动脉IMT和弹性的影响大于单个CVRF成分。这表明CVRF的组分相互作用以协同影响颈动脉IMT和弹性。
Background Carotid intima-media thickness (IMT) and elasticity have been shown to be independent predictors of cardiovascular disease (CVD). Cardiovascular risk factors (CVRFs) includes hypertension, dyslipidemia, diabetes, overweight and smoking. The objective was to investigate whether the clustering of three or more components of CVRFs has a greater impact on carotid IMT and elasticity than individual components of CVRFs. Methods One hundred and seventy-three participants without clinical CVD were classified as the multiple CVRFs patients with three or more CVRFs (n = 55) and control group with two or less CVRFs (n = 118). Carotid IMT and elastic modulus were measured by B-mode ultrasound and vessel texture matching method (VTMM), respectively. Results The multiple CVRFs conferred a disproportionate increase in carotid IMT (43%, p<0.0001) and elastic modulus (60%, p<0.0001), compared with control group. Multiple regression models, which included age, gender, as well as each individual component of CVRFs as continuous variables, showed that multiple CVRFs was an independent determinant of both IMT (p = 0.042) and elasticity (p = 0.008). In the analysis of variance adjusted with age, subjects with single, double, and multiple CVRFs, increased by 8.1%, 42.2%, and 66% for IMT, 54.6%, 94.3%, and 125.2% for elastic modulus, respectively, compared to subjects without CVRFs. Conclusions The clustering of multiple CVRFs has a greater impact on carotid IMT and elasticity than individual components of CVRFs. This suggests that the components of CVRFs interact to synergistically impact carotid IMT and elasticity.
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