The association of pediatric low- and high-density lipoprotein cholesterol dyslipidemia classifications and change in dyslipidemia status with carotid intima-media thickness in adulthood evidence from the cardiovascular risk in Young Finns study, the Bogalusa Heart study, and the CDAH (Childhood Determinants of Adult Health) study.
The association of pediatric low- and high-density lipoprotein cholesterol dyslipidemia classifications and change in dyslipidemia status with carotid intima-media thickness in adulthood evidence from the cardiovascular risk in Young Finns study, the Bogalusa Heart study, and the CDAH (Childhood Determinants of Adult Health) study.
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DOI：
10.1016/j.jacc.2008.09.061
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发表时间：
2009-03-10
影响因子：
24
通讯作者：
Raitakari, Olli T.
中科院分区：
文献类型：
--
作者：
Magnussen, Costan G.;Venn, Alison;Thomson, Russell;Juonala, Markus;Srinivasan, Sathanur R.;Viikari, Jorma S. A.;Berenson, Gerald S.;Dwyer, Terence;Raitakari, Olli T.
– 确定国家胆固醇教育计划 (NCEP) 或国家健康和营养检查调查 (NHANES) 青少年血脂异常状态的 LDL-胆固醇和 HDL-胆固醇分类中哪一个最能有效预测成年后颈总动脉内膜中层厚度 (IMT) 高。 – 提出了儿童血脂异常状态的两种分类。没有研究评估其中哪一种对于预测青少年在成年后会出现临床前动脉粥样硬化最有效。 – 三项基于人群的前瞻性队列研究收集了 1711 名 12-18 岁青少年的脂蛋白测量值，并在 29-39 岁的年轻人时重新测量。青春期的脂蛋白根据 NCEP 和 NHANES 切点进行分类，而成年期的高 IMT 定义为年龄、性别、种族和队列特定 IMT 90% 或以上的脂蛋白。 – 与所采用的分类无关，患有血脂异常的青少年在成年后出现高 IMT 的风险显着增加（相对风险从 1.6 到 2.5）。两种分类之间的预测能力差异很小。与不具有这两种危险因素的青少年相比，患有血脂异常的超重或肥胖青少年成年后颈动脉IMT（男性，0.11毫米；女性，0.08毫米）增加。与血脂异常状态的变化相比，青少年血脂异常状态与成年期高 IMT 的相关性更强。 – 儿童血脂异常分类在预测成年早期 IMT 高风险增加的青少年方面表现相同。我们的数据表明，血脂异常筛查可能仅限于超重或肥胖的青少年。
– To determine which of the National Cholesterol Education Program (NCEP) or National Health and Nutrition Examination Survey (NHANES) LDL-cholesterol and HDL-cholesterol classifications of dyslipidemia status in adolescents is most effective at predicting high common carotid artery intima-media thickness (IMT) in adulthood. – Two classifications of pediatric dyslipidemia status have been proposed. No study has assessed which of these is most effective for predicting adolescents who will develop preclinical atherosclerosis in adulthood. – Three population-based, prospective cohort studies that collected lipoprotein measurements on 1711 adolescents aged 12–18 years who were re-measured as young adults aged 29–39 years. Lipoproteins in adolescence were classified according to NCEP and NHANES cut-points, while high IMT in adulthood was defined as those at or above the age, sex, race, and cohort specific 90th percentile of IMT. – Independent of the classification employed, adolescents with dyslipidemia were at significantly increased risk of having high IMT in adulthood (relative risks from 1.6 to 2.5). Differences in predictive capacity between both classifications were minimal. Overweight or obese adolescents with dyslipidemia had increased carotid IMT (males, 0.11mm; females, 0.08mm) in adulthood compared with those who did not have both risk factors. Adolescent dyslipidemia status was more strongly associated with high IMT in adulthood than change in dyslipidemia status. – Pediatric dyslipidemia classifications perform equally in the prediction of adolescents who are at increased risk of high IMT in young adulthood. Our data suggest that dyslipidemia screening could be limited to overweight or obese adolescents.
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影响因子：
37.8
作者：
DWYER, T;GIBBONS, LE
通讯作者：
GIBBONS, LE
影响因子：
37.8
作者：
Jolliffe, Courtney J.;Janssen, Ian
通讯作者：
Janssen, Ian
影响因子：
2.9
作者：
Magnussen, Costan G.;Fryer, Jayne;Raitakari, Olu T.
通讯作者：
Raitakari, Olu T.
影响因子：
5
作者：
PORKKA, KVK;VIIKARI, JSA;AKERBLOM, HK
通讯作者：
AKERBLOM, HK
影响因子：
37.8
作者：
Davis, PH;Dawson, JD;Lauer, RM
通讯作者：
Lauer, RM