Biomaterials for recruiting and activating endogenous stem cells in situ tissue regeneration.
Biomaterials for recruiting and activating endogenous stem cells in situ tissue regeneration.
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DOI:
10.1016/j.actbio.2022.03.014
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发表时间:
2022-04-15
影响因子:
9.7
通讯作者:
Embree, Mildred C.
中科院分区:
文献类型:
--
作者:
Safina, Ingrid;Embree, Mildred C.
关键词:
Over the past two decades in situ tissue engineering has emerged as a new approach where biomaterials are used to harness the body’s own stem/progenitor cells to regenerate diseased or injured tissue. Immunomodulatory biomaterials are designed to promote a regenerative environment, recruit resident stem cells to diseased or injured tissue sites, and direct them towards tissue regeneration. This review explores advances gathered from in vitro and in vivo studies on in situ tissue regenerative therapies. Here we also examine the different ways this approach has been incorporated into biomaterial sciences in order to create customized biomaterial products for therapeutic applications in a broad spectrum of tissues and diseases.
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