Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs.
Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs.
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高危 HIV-1 血清阴性血友病患者中人类免疫缺陷病毒 (HIV) 1 型感染状况和体外对 HIV 感染的易感性。
DOI：
10.1093/infdis/172.1.228
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kiger,KP
中科院分区：
文献类型：
--
作者：
Lederman,MM;Jackson,JB;Kroner,BL;White3rd,GC;Eyster,ME;Aledort,LM;Hilgartner,MW;Kessler,CM;Cohen,AR;Kiger,KP
Blood samples were obtained from 16 hemophiliacs who had a 50%–94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P< .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%–56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.
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