Serum alkaline phosphatase and infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-cohort study
Serum alkaline phosphatase and infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-cohort study
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血液透析患者的血清碱性磷酸酶和感染相关死亡率：Q 队列研究的十年结果
DOI：
10.1007/s10157-022-02255-4
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发表时间：
2022
影响因子：
2.3
通讯作者：
Kitazono Takanari
中科院分区：
文献类型：
--
作者：
Kitamura Hiromasa;Yotsueda Ryusuke;Hiyamuta Hiroto;Taniguchi Masatomo;Tanaka Shigeru;Yamada Shunsuke;Tsuruya Kazuhiko;Nakano Toshiaki;Kitazono Takanari
高血清碱性磷酸酶（ALP）水平与血液透析（HD）患者的高全因死亡率和心血管死亡率相关。然而，血清ALP水平和感染相关的mortality.MethodsA共3502维持HD患者的长期关系仍不清楚在Q-队列研究，在日本的观察性队列研究登记。主要结局是10年随访期间感染相关死亡率。关注的协变量为基线时的血清ALP水平。血清ALP水平和感染相关的死亡率之间的关联使用考克斯比例风险模型和细灰色子分布风险模型与非感染相关的死亡作为竞争risk.ResultsDuring随访期间，446例患者死于感染。根据基线血清ALP水平，将患者分为性别特异性四分位数（Q1-Q4）。与血清ALP最低四分位数（Q1）的患者相比，血清ALP最高四分位数（Q4）的患者感染相关死亡率的多变量校正风险比（HR）显著更高，为1.70 [95%置信区间（CI）1.24-2.32]。此外，血清ALP水平每升高50 U/L，感染相关死亡率的HR为1.24（95% CI 1.12-1.36）。这些相关性在竞争风险模型中保持一致：Q4与Q1相比的子分布HR为1.47; 95%CI为1.07-2.03。结论在接受HD的患者中，较高的血清ALP水平与较高的感染相关死亡风险显著相关。
BackgroundHigh serum alkaline phosphatase (ALP) levels are associated with excess all-cause and cardiovascular mortality in patients undergoing hemodialysis (HD). However, the long-term relationship between serum ALP levels and infection-related mortality remains unclear.MethodsA total of 3502 maintenance HD patients were registered in the Q-Cohort Study, an observational cohort study in Japan. The primary outcome was infection-related mortality during a 10-year follow-up period. The covariate of interest was serum ALP levels at baseline. The association between serum ALP levels and infection-related mortality was calculated using a Cox proportional hazards model and a Fine–Gray subdistribution hazards model with non-infection-related death as a competing risk.ResultsDuring the follow-up period, 446 patients died of infection. According to their baseline serum ALP levels, the patients were categorized into sex-specific quartiles (Q1–Q4). Compared with patients in the lowest serum ALP quartile (Q1), those in the highest quartile (Q4) had a significantly higher multivariable-adjusted hazard ratio (HR) of 1.70 [95% confidence interval (CI) 1.24–2.32] for infection-related mortality. Furthermore, the HR for every 50 U/L increase in serum ALP levels was 1.24 (95% CI 1.12–1.36) for infection-related mortality. These associations remained consistent in the competing risk model: subdistribution HR, 1.47; 95% CI 1.07–2.03 for Q4 compared with Q1.ConclusionHigher serum ALP levels were significantly associated with a higher risk of infection-related mortality in patients undergoing HD.
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DOI：
10.2215/cjn.11501210
发表时间：
2011-09-01
影响因子：
9.8
作者：
Akizawa, Tadao;Kido, Ryo;Kurokawa, Kiyoshi
通讯作者：
Kurokawa, Kiyoshi
慢性肾功能衰竭患者的血清碱性磷酸酶同工酶模式。
DOI：
10.1016/0009-8981(77)90042-0
发表时间：
1977
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
A. Skillen;A. Pierides
通讯作者：
A. Pierides
影响因子：
3.4
作者：
Eriguchi, Rieko;Taniguchi, Masatomo;Kitazono, Takanari
通讯作者：
Kitazono, Takanari
[JSCC推荐方法的未来讨论主题]。
DOI：
--
发表时间：
2016
期刊：
Rinsho byori. The Japanese journal of clinical pathology
影响因子：
--
作者：
S. Yamadate;T. Nakayama
通讯作者：
T. Nakayama
影响因子：
2.3
作者：
Hiyamuta, Hiroto;Yamada, Shunsuke;Kitazono, Takanari
通讯作者：
Kitazono, Takanari