The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study.
The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study.
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DOI：
10.1186/s11689-015-9114-9
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发表时间：
2015
影响因子：
4.9
通讯作者：
Whitehouse AJ
中科院分区：
文献类型：
--
作者：
Jamnadass ES;Keelan JA;Hollier LP;Hickey M;Maybery MT;Whitehouse AJ
产前雄激素暴露被假设与自闭症谱系障碍（ASD）有关。虽然之前的研究发现羊水中的睾酮水平与自闭症样特征之间存在联系，但在脐带血中的睾酮水平中尚未发现类似的关系。然而，可能是多种雄激素和雌激素的净生物活性影响了产前性类固醇的产后效果。因此，研究人员调查了雄激素(A)和雌激素(E)的复合水平，以及它们的比例，以及它们与年轻成年期自闭症样特征的关系。860例分娩时脐带血中的性类固醇数据可用。分析样品中的雄激素（睾酮、雄烯二酮和脱氢表雄酮）和雌激素（雌酮、雌二醇、雌三醇和雌二醇）。测量生物可利用睾酮、雌二醇和雌酮水平，并用于计算A和E复合物以及A / E比值。183名男性（M = 20.10岁，SD = 0.65岁）和189名女性（M =19.92岁，SD = 0.68岁）在成年早期与参与者接触，以完成自闭症谱系商（AQ）作为自闭症样特征的自我报告测量。雄性的雄激素复合物和A / E复合物比显著高于雌性。男性在AQ的细节/模式子量表上得分也明显更高。随后的分类和连续分析（考虑协变量）显示，A/E复合材料或A/E比率与AQ总分或子量表得分之间没有实质性的关系。目前的研究发现，脐带血的A/E复合物或A/E比值与AQ测量的人群中自闭症样特征之间没有联系。这些结果并不排除这些性类固醇变量可能预测早期发育中其他神经发育特征的可能性。本文的在线版本（doi:10.1186/s11689- 015-91114 -9）包含补充材料，授权用户可以使用。
Prenatal androgen exposure has been hypothesized to be linked to autism spectrum disorder (ASD). While previous studies have found a link between testosterone levels in amniotic fluid and autistic-like traits, a similar relationship has not been found for testosterone in umbilical cord blood. However, it may be the net biological activity of multiple androgens and estrogens that influences postnatal effects of prenatal sex steroids. Accordingly, composite levels of androgens (A) and estrogens (E) were investigated, along with their ratio, in relation to autistic-like traits in young adulthood. Sex steroid data in umbilical cord blood were available from 860 individuals at delivery. Samples were analyzed for androgens (testosterone, androstenedione, and dehydroepiandrosterone) and estrogens (estrone, estradiol, estriol, and estetrol). Levels of bioavailable testosterone, estradiol, and estrone were measured and used to calculate A and E composites and the A to E ratio. Participants were approached in early adulthood to complete the autism-spectrum quotient (AQ) as a self-report measure of autistic-like traits, with 183 males (M = 20.10 years, SD = 0.65 years) and 189 females (M =19.92 years, SD = 0.68 years) providing data. Males exhibited significantly higher androgen composites and A to E composite ratios than females. Males also scored significantly higher on the details/patterns subscale of the AQ. Subsequent categorical and continuous analyses, which accounted for covariates, revealed no substantial relationships between the A/E composites or the A to E ratio and the AQ total or subscale scores. The current study found no link between the A/E composites or the A to E ratio in cord blood and autistic-like traits in the population as measured by the AQ. These outcomes do not exclude the possibility that these sex steroid variables may predict other neurodevelopmental traits in early development. The online version of this article (doi:10.1186/s11689-015-9114-9) contains supplementary material, which is available to authorized users.
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影响因子：
3.9
作者：
Anello, Alene;Reichenberg, Abraham;Luo, Xiaodong;Schmeidler, James;Hollander, Eric;Smith, Christopher J.;Puleo, Connor M.;Kryzak, Lauren A.;Silverman, Jeremy M.
通讯作者：
Silverman, Jeremy M.
影响因子：
5.8
作者：
Handelsman, David J.
通讯作者：
Handelsman, David J.
影响因子：
11.2
作者：
CHI, JG;DOOLING, EC;GILLES, FH
通讯作者：
GILLES, FH
影响因子：
3.5
作者：
Arnold AP
通讯作者：
Arnold AP
影响因子：
4.5
作者：
Giarelli E;Wiggins LD;Rice CE;Levy SE;Kirby RS;Pinto-Martin J;Mandell D
通讯作者：
Mandell D