Evidence suggesting common mechanisms underlie contralateral and ipsilateral negative BOLD responses in the human visual cortex.
Evidence suggesting common mechanisms underlie contralateral and ipsilateral negative BOLD responses in the human visual cortex.
复制标题
DOI：
10.1016/j.neuroimage.2022.119440
复制
发表时间：
2022-11-15
期刊：
影响因子：
5.7
通讯作者：
Razlighi QR
中科院分区：
文献类型：
--
作者：
He H;Ettehadi N;Shmuel A;Razlighi QR
对单侧视觉半野刺激的任务诱发的正BOLD反应（PBR）通常伴随着视觉皮质中对侧和同侧的强烈且持续的负BOLD反应（NBR）。这两种类型的NBR的信号特征和神经和/或血管机制尚未完全了解。在本文中，我们研究了这两种类型的NBR的性能。我们首先证明了这两个NBR的线性相对于刺激持续时间。接下来，我们发现两种NBR的血流动力学反应函数（HRF）彼此相似，但与PBR的血流动力学反应函数显著不同。此外，两个NBR的主题式表达紧密耦合的程度，两个NBR之间的相关性显着高于每个NBR和PBR之间的相关性。然而，两个NBR的激活模式并没有表现出高度的半球间空间相似性，它们之间的功能连接是没有什么不同的NBR和PBR之间的半球间的功能连接。最后，虽然注意力确实调节了两种NBR，但它们的HRF中与注意力相关的变化是相似的。我们的研究结果表明，这两个NBR可能是通过共同的神经和/或血管机制，涉及远端/深部脑区，项目的两个半球。
The task-evoked positive BOLD response (PBR) to a unilateral visual hemi-field stimulation is often accompanied by robust and sustained contralateral as well as ipsilateral negative BOLD responses (NBRs) in the visual cortex. The signal characteristics and the neural and/or vascular mechanisms that underlie these two types of NBRs are not completely understood. In this paper, we investigated the properties of these two types of NBRs. We first demonstrated the linearity of both NBRs with respect to stimulus duration. Next, we showed that the hemodynamic response functions (HRFs) of the two NBRs were similar to each other, but significantly different from that of the PBR. Moreover, the subject-wise expressions of the two NBRs were tightly coupled to the degree that the correlation between the two NBRs was significantly higher than the correlation between each NBR and the PBR. However, the activation patterns of the two NBRs did not show a high level of interhemispheric spatial similarity, and the functional connectivity between them was not different than the interhemispheric functional connectivity between the NBRs and PBR. Finally, while attention did modulate both NBRs, the attention-related changes in their HRFs were similar. Our findings suggest that the two NBRs might be generated through common neural and/or vascular mechanisms involving distal/deep brain regions that project to the two hemispheres.
登录
查看更多内容
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
1.8
作者：
Bressler, David W.;Fortenbaugh, Francesca C.;Robertson, Lynn C.;Silver, Michael A.
通讯作者：
Silver, Michael A.
影响因子：
16.2
作者：
Goense J;Merkle H;Logothetis NK
通讯作者：
Logothetis NK
影响因子：
4.3
作者：
Benson NC;Butt OH;Brainard DH;Aguirre GK
通讯作者：
Aguirre GK
影响因子：
2.9
作者：
Fabri, Mara;Polonara, Gabriele;Manzoni, Tullio
通讯作者：
Manzoni, Tullio