Dickkopf-3: Current Knowledge in Kidney Diseases.
Dickkopf-3: Current Knowledge in Kidney Diseases.
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Dickkopf-3：肾脏疾病的最新知识
DOI：
10.3389/fphys.2020.533344
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发表时间：
2020
影响因子：
4
通讯作者：
Ke B
中科院分区：
文献类型：
--
作者：
Fang X;Hu J;Chen Y;Shen W;Ke B
Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney disease progression and assessing the effects of interventions. We review the biological role of DKK3 as an agonist in chronic kidney disease (CKD) and autosomal dominant polycystic kidney disease (ADPKD) and as an antagonist in idiopathic membranous nephropathy (IMN). In addition, we present the clinical applications of DKK3 in acute kidney disease and tubulointerstitial fibrosis, suggesting that urine DKK3 may be a potential biomarker for acute kidney disease and CKD. Further research into the mechanism of DKK3 and its use as a diagnostic tool, alone or in combination with other biomarkers, could prove clinically useful for better understanding the pathology of kidney diseases and improving early detection and treatment.
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影响因子：
64.8
作者：
Glinka, A;Wu, W;Niehrs, C
通讯作者：
Niehrs, C
Krüppel样因子4在肾纤维化中的作用。
影响因子：
4
作者：
Ke B;Zhang A;Wu X;Fang X
通讯作者：
Fang X
DKK3 (Dickkopf 3) 改变涉及血管祖细胞和成纤维细胞分化为平滑肌细胞的动脉粥样硬化斑块表型
DOI：
10.1161/atvbaha.117.310079
发表时间：
2018-02-01
影响因子：
8.7
作者：
Karamariti, Eirini;Zhai, Chungang;Xu, Qingbo
通讯作者：
Xu, Qingbo
影响因子：
7.8
作者：
Miao, Jinhua;Liu, Jiafeng;Zhou, Lili
通讯作者：
Zhou, Lili
DOI：
10.1007/s00424-017-2018-7
发表时间：
2017-08
期刊：
Pflugers Archiv : European journal of physiology
影响因子：
--
作者：
Gröne EF;Federico G;Nelson PJ;Arnold B;Gröne HJ
通讯作者：
Gröne HJ