Urinary metabonomics for diagnosis of depression in hepatitis B virus-infected patients.
Urinary metabonomics for diagnosis of depression in hepatitis B virus-infected patients.
复制标题
DOI：
10.5812/ircmj.17(4)2015.27359
复制
发表时间：
2015-04
影响因子：
0.4
通讯作者：
Shen BS
中科院分区：
文献类型：
--
作者：
Hou LJ;Wang HW;Wei XX;Duan SP;Zhuo Y;Song XW;Shen BS
抑郁症是伴随着B肝炎病毒（HBV）感染的患者，并降低这些患者的生活质量。然而，没有基于实验室的方法来客观地诊断这种疾病。本研究的目的是探讨HBV感染后抑郁患者尿代谢产物的变化。在这项研究中，招募了81名抑郁的HBV感染患者，68名非抑郁的HBV感染患者和64名健康对照（HC）。一个核磁共振（NMR）为基础的尿代谢组学方法被用来表征尿代谢谱的抑郁症和非抑郁症的主题。鉴定了17种不同的尿代谢产物，这些代谢产物负责区分抑郁的HBV感染患者与非抑郁的HBV感染患者和HC。在这些代谢物中，丙酮酸、异丁酸、N-甲基烟酰胺、α-羟基丁酸、乙酰乙酸和丙二酸被确定为诊断HBV感染患者抑郁症的潜在生物标志物。这些潜在生物标志物的组合面板可以有效区分抑郁的HBV感染患者与非抑郁的HBV感染患者和HC，在训练集中的平均准确度为89.6%，在测试集中的预测准确度为86.4%。这些结果表明，基于NMR的尿液代谢组学方法可能是一个有用的工具，为HBV感染患者的抑郁症的临床诊断和6个潜在的生物标志物可能有助于开发一个客观的诊断方法。受招募受试者数量的限制，需要未来的研究来验证我们的结论。
Depression is concomitantly presented in Hepatitis B Virus (HBV)-infected patients and decreases these patients’ quality of life. However, there are no laboratory-based methods to objectively diagnose this disorder. The aim of this study was to investigate the alteration of urinary metabolites in depressed HBV-infected patients. In this study, 81 depressed HBV-infected patients, 68 non-depressed HBV-infected patients and 64 Healthy Controls (HC) were recruited. A nuclear magnetic resonance (NMR)-based urinary metabonomic method was used to characterize the urinary metabolic profiling of depressed and non-depressed subjects. Seventeen differential urinary metabolites responsible for discriminating depressed HBV-infected patients from non-depressed HBV-infected patients and HC were identified. Among these metabolites, pyruvate, isobutyrate, N-methylnicotinamide, α-hydroxybutyrate, acetoacetate and malonate were identified as potential biomarkers for diagnosing depression in HBV-infected patients. A combined panel of these potential biomarkers could effectively discriminate depressed HBV-infected patients from non-depressed HBV-infected patients and HC, with an average accuracy of 89.6% in the training set and a predictive accuracy of 86.4% in the test set. These findings suggest that NMR-based urinary metabonomics approach might be a useful tool for the clinical diagnosis of depression in HBV-infected patients and the six potential biomarkers could be helpful for developing an objective diagnostic method. Limited by the number of recruited subjects, future studies are required to validate our conclusions.
登录
查看更多内容
影响因子：
6.7
作者：
Marcellin, Patrick;Lau, George K. K.;Pluck, Nigel
通讯作者：
Pluck, Nigel
DOI：
10.1046/j.1440-1746.2002.02669.x
发表时间：
2002-02-01
影响因子：
4.1
作者：
McDonald, J;Jayasuriya, R;Gluseska, S
通讯作者：
Gluseska, S
影响因子：
2.9
作者：
Tafet, Gustavo E.;Idoyaga-Vargas, Victor P.;Shinitzky, Meir
通讯作者：
Shinitzky, Meir
影响因子：
6.6
作者：
Chen, LS;Eaton, WW;Nestadt, G
通讯作者：
Nestadt, G
精神分裂症的潜在代谢标志物
影响因子：
11
作者：
Yang J;Chen T;Sun L;Zhao Z;Qi X;Zhou K;Cao Y;Wang X;Qiu Y;Su M;Zhao A;Wang P;Yang P;Wu J;Feng G;He L;Jia W;Wan C
通讯作者：
Wan C