Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia.
Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia.
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DOI：
10.1038/s41467-022-35338-7
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发表时间：
2022-12-09
影响因子：
16.6
通讯作者：
Lin, Qiang
中科院分区：
文献类型：
--
作者：
Liu, Yali;Qu, Meng;Jiang, Han;Schneider, Ralf;Qin, Geng;Luo, Wei;Yu, Haiyan;Zhang, Bo;Wang, Xin;Zhang, Yanhong;Zhang, Huixian;Zhang, Zhixin;Wu, Yongli;Zhang, Yingyi;Yin, Jianping;Zhang, Si;Venkatesh, Byrappa;Roth, Olivia;Meyer, Axel;Lin, Qiang
在高度衍生的同节鱼类(笛鱼、海豚和海马)中，性别角色颠倒的孵化行为的进化最终导致海马世系的雄性怀孕，其雄性的特征是有一个专门的孵卵袋，雌性在交配时将卵放入其中。然后，卵子被胎盘状组织紧密地吞噬，这有助于气体和营养物质的交换。由于父亲对同种异体胚胎具有免疫耐受性，因此认为男性妊娠与特定的免疫适应是共同进化的。事实上，我们在这里证明了tlx1转录因子中特定的氨基酸替换与海马的无脾(失去免疫系统中的一个器官)有关，CRISPR-Cas9使用斑马鱼的实验证实了这一点。跨联体系统发育的比较基因组学显示，随着父母照顾强度的增加，免疫系统基因谱系的复杂性降低。免疫遗传改变和男性怀孕的同步进化支持了男性怀孕与胚胎的免疫耐受性共同进化的概念。海马可能需要适应，以避免雄性对同种异体胚胎的免疫排斥。作者发现，tlx1基因的单个替换与海马的脾丧失有关，而在整个支系中，男性怀孕的程度与免疫基因谱系的复杂性呈负相关。
In the highly derived syngnathid fishes (pipefishes, seadragons & seahorses), the evolution of sex-role reversed brooding behavior culminated in the seahorse lineage’s male pregnancy, whose males feature a specialized brood pouch into which females deposit eggs during mating. Then, eggs are intimately engulfed by a placenta-like tissue that facilitates gas and nutrient exchange. As fathers immunologically tolerate allogenic embryos, it was suggested that male pregnancy co-evolved with specific immunological adaptations. Indeed, here we show that a specific amino-acid replacement in the tlx1 transcription factor is associated with seahorses’ asplenia (loss of spleen, an organ central in the immune system), as confirmed by a CRISPR-Cas9 experiment using zebrafish. Comparative genomics across the syngnathid phylogeny revealed that the complexity of the immune system gene repertoire decreases as parental care intensity increases. The synchronous evolution of immunogenetic alterations and male pregnancy supports the notion that male pregnancy co-evolved with the immunological tolerance of the embryo. Seahorses may have required adaptations to avoid immunological rejection of allogenic embryos by males. The authors show that a single substitution in tlx1 is associated with loss of the spleen in seahorses, and that across the clade, degree of male pregnancy is negatively correlated with immune gene repertoire complexity.
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影响因子：
3.3
作者：
Dubin, Arseny;Jorgensen, Tor Erik;Jakt, Lars Martin
通讯作者：
Jakt, Lars Martin
DOI：
10.1038/nrg2703
发表时间：
2010-01
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
10.7
作者：
Minh BQ;Nguyen MA;von Haeseler A
通讯作者：
von Haeseler A
影响因子：
12.3
作者：
Haas, Brian J.;Salzberg, Steven L.;Zhu, Wei;Pertea, Mihaela;Allen, Jonathan E.;Orvis, Joshua;White, Owen;Buell, C. Robin;Wortman, Jennifer R.
通讯作者：
Wortman, Jennifer R.
影响因子：
16.8
作者：
Fernandez, Rosa;Gabaldon, Toni
通讯作者：
Gabaldon, Toni