The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study.
The relationship between glutamate, dopamine, and cortical gray matter: A simultaneous PET-MR study.
复制标题
谷氨酸，多巴胺和皮质灰质之间的关系：同时进行的PET-MR研究。
DOI：
10.1038/s41380-022-01596-6
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发表时间：
2022-08
影响因子：
11
通讯作者：
McCutcheon, Robert A.
中科院分区：
文献类型：
--
作者：
Rogeau, Antoine;Nordio, Giovanna;Veronese, Mattia;Brown, Kirsten;Nour, Matthew M.;Osugo, Martin;Jauhar, Sameer;Howes, Oliver D.;McCutcheon, Robert A.
临床前研究表明，前额叶皮质通过谷氨酸能机制调节纹状体的多巴胺能功能。这些系统的同时中断也经常见于神经精神疾病。因此，纹状体多巴胺信号、皮质灰质和谷氨酸水平的同时测量引起了人们的极大兴趣，但以前还没有报道。在目前的研究中，28名健康受试者进行了两次同时的[11C]-( + )-PHNOPET-MRI扫描，一次服用安慰剂，一次服用安非他明，采用双盲随机交叉设计，同时测量纹状体多巴胺释放、纹状体多巴胺受体(D2/3R)可获得性、前扣带回谷氨酸+谷氨酰胺(Glx)水平和皮质灰质体积。基于体素的形态计量学被用来调查神经化学测量和灰质体积之间的关系。整个纹状体D2/3R的可用性与前额叶皮质灰质体积呈正相关(pFWE校正 = 0.048)。这种关系主要是由联合受体的可用性驱动的(pFWE校正后的 = 0.023)。此外，还观察到感觉运动纹状体D2/3R可用性和前扣带回GLX之间的交互作用，即在前扣带回GLX浓度较高的个体中，D2/3R可用性与右侧额叶皮质灰质体积负相关，而在前扣带回GLX水平较低的个体中观察到正D2/3R灰质关联(pFWE校正 = 0.047)。这些结果与前额叶皮质参与纹状体多巴胺功能调节的假设是一致的。此外，观察到的关联增加了这种调节可能受前扣带回谷氨酸浓度的调节的可能性。
Prefrontal cortex has been shown to regulate striatal dopaminergic function via glutamatergic mechanisms in preclinical studies. Concurrent disruption of these systems is also often seen in neuropsychiatric disease. The simultaneous measurement of striatal dopamine signaling, cortical gray matter, and glutamate levels is therefore of major interest, but has not been previously reported. In the current study, twenty-eight healthy subjects underwent 2 simultaneous [11C]-( + )-PHNO PET-MRI scans, once after placebo and once after amphetamine in a double-blind randomized cross-over design, to measure striatal dopamine release, striatal dopamine receptor (D2/3R) availability, anterior cingulate glutamate+glutamine (Glx) levels, and cortical gray matter volumes at the same time. Voxel-based morphometry was used to investigate associations between neurochemical measures and gray matter volumes. Whole striatum D2/3R availability was positively associated with prefrontal cortex gray matter volume (pFWE corrected = 0.048). This relationship was mainly driven by associative receptor availability (pFWE corrected = 0.023). In addition, an interaction effect was observed between sensorimotor striatum D2/3R availability and anterior cingulate Glx, such that in individuals with greater anterior cingulate Glx concentrations, D2/3R availability was negatively associated with right frontal cortex gray matter volumes, while a positive D2/3R-gray matter association was observed in individuals with lower anterior cingulate Glx levels (pFWE corrected = 0.047). These results are consistent with the hypothesis that the prefrontal cortex is involved in regulation of striatal dopamine function. Furthermore, the observed associations raise the possibility that this regulation may be modulated by anterior cingulate glutamate concentrations.
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影响因子：
4.8
作者：
Kurose S;Kubota M;Takahata K;Yamamoto Y;Fujiwara H;Kimura Y;Ito H;Takeuchi H;Mimura M;Suhara T;Higuchi M
通讯作者：
Higuchi M
DOI：
10.1056/nejmoa2017015
发表时间：
2021-02-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brannan SK;Sawchak S;Miller AC;Lieberman JA;Paul SM;Breier A
通讯作者：
Breier A
影响因子：
11
作者：
D'Ambrosio E;Jauhar S;Kim S;Veronese M;Rogdaki M;Pepper F;Bonoldi I;Kotoula V;Kempton MJ;Turkheimer F;Kwon JS;Kim E;Howes OD
通讯作者：
Howes OD
影响因子：
5.7
作者：
Gunn, RN;Lammertsma, AA;Cunningham, VJ
通讯作者：
Cunningham, VJ
影响因子：
9.3
作者：
Gallezot, Jean-Dominique;Zheng, Ming-Qiang;Malison, Robert T.
通讯作者：
Malison, Robert T.