Feline oncornavirus-associated cell membrane antigen: a viral and not a cellularly coded transformation-specific antigen of cat lymphomas.
Feline oncornavirus-associated cell membrane antigen: a viral and not a cellularly coded transformation-specific antigen of cat lymphomas.
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猫冠状病毒相关细胞膜抗原：一种病毒而非细胞编码的猫淋巴瘤转化特异性抗原。
DOI：
10.1016/0042-6822(83)90360-4
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发表时间：
1983
期刊：
影响因子：
3.7
通讯作者：
Prensky,W
中科院分区：
文献类型：
--
作者：
Vedbrat,SS;Rasheed,S;Lutz,H;Gonda,MA;Ruscetti,S;Gardner,MB;Prensky,W
The feline oncornavirus-associated cell membrane antigen (FOCMA) was defined as a tumor antigen common to cat lymphomas and fibrosarcomas induced by feline leukemia virus (FeLV) and feline sarcoma virus (FeSV), respectively. The antigen was recognized by sera from cats thought to be resistant to leukemogenesis. We report here that a common denominator in the activity of naturally occurring viremic cat antisera to FOCMA is, in fact, their reactivity to FeLV C antigenic determinants. The cat antisera, monoclonal antibodies to FOCMA, and monoclonal antibodies to FeLV C, all reacted in immunofiuorescence assays with FeLV C-infected cells and immunoprecipitated a molecule electrophoretically indistinguishable from envelope glycoprotein of FeLV. Viremic cat antisera to FOCMA bound to budding virus particles of FeLV C-infected cells, even though some of them could not be absorbed by mature virion proteins. Thus, the unusual feature of cat antibodies to FOCMA is their binding to nascent but not to mature virus particles. FOCMA-positive cat lymphomas expressed antigenic determinants of FeLV-C gp70, with or without productive infection. FeLV-negative tumors not expressing FeLV C gp70 were also FOCMA negative. Furthermore, most of the viremic cat sera and the monoclonal antibodies to FOCMA did not react with FeSV-transformed nonproducer cells. The absence of FOCMA from these cells and from FeLV-negative lymphoid tumors and its presence in FeLV-C infected fibroblasts indicated that this antigen is virus encoded and not a cellular tumor-specific antigen.
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自然环境中猫白血病病毒的生物学。
影响因子：
11.2
作者：
W. Hardy;P. Hess;E. MacEwen;A. McClelland;E. Zuckerman;M. Essex;S. Cotter;O. Jarrett
通讯作者：
O. Jarrett
影响因子：
6.4
作者：
P. Russell;O. Jarrett
通讯作者：
O. Jarrett
猫冠状病毒相关细胞膜抗原。
DOI：
10.1093/jnci/54.3.637
发表时间：
1975
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
M. Essex;R. Jakowski;W. Hardy;S. Cotter;P. Hess;A. Sliski
通讯作者：
A. Sliski
肿瘤病毒蛋白作为细胞抗原。
影响因子：
--
作者：
Erwin Fleissner;Harry W. Snyder
通讯作者：
Harry W. Snyder
影响因子：
4.4
作者：
S. Kessler
通讯作者：
S. Kessler