Uncovering a tripartite landmark in posterior cingulate cortex.

Uncovering a tripartite landmark in posterior cingulate cortex.
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DOI:
10.1126/sciadv.abn9516
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发表时间:
2022-09-09
期刊:
影响因子:
13.6
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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理解大脑结构与功能的关系,以及它们的发展和进化,是神经科学研究的核心。本研究表明,脑功能网络枢纽后扣带皮层(PCC)的形态学差异可以预测PCC宏观解剖、微观结构和功能特征的个体差异。人工标记572个大脑半球的4511个脑沟,我们在PCC内发现了一个浅皮层凹痕(称为边缘下沟;ifms),该凹痕在神经解剖学图谱中是缺失的,但与与认知控制有关的外侧额顶叶网络的局灶功能区域共定位。这种结构-功能耦合推广到包含数百项研究和数千名参与者的荟萃分析。另外的形态学分析表明,在不同的生命周期和不同的类人猿物种之间,这些纹样的独特性质是不同的。这些发现支持了一个经典理论,即浅的第三沟是联合皮层的标志。它们也提出了一个问题:我们还遗漏了多少皮层凹痕?一种以前未知的大脑结构将功能和解剖组织联系在一起,并在不同的生命周期和物种中有所不同。
Understanding brain structure-function relationships, and their development and evolution, is central to neuroscience research. Here, we show that morphological differences in posterior cingulate cortex (PCC), a hub of functional brain networks, predict individual differences in macroanatomical, microstructural, and functional features of PCC. Manually labeling 4511 sulci in 572 hemispheres, we found a shallow cortical indentation (termed the inframarginal sulcus; ifrms) within PCC that is absent from neuroanatomical atlases yet colocalized with a focal, functional region of the lateral frontoparietal network implicated in cognitive control. This structural-functional coupling generalized to meta-analyses consisting of hundreds of studies and thousands of participants. Additional morphological analyses showed that unique properties of the ifrms differ across the life span and between hominoid species. These findings support a classic theory that shallow, tertiary sulci serve as landmarks in association cortices. They also beg the question: How many other cortical indentations have we missed? A previously uncharted brain structure links functional and anatomical organization and differs across the life span and species.
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