Uncovering a tripartite landmark in posterior cingulate cortex.
Uncovering a tripartite landmark in posterior cingulate cortex.
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DOI:
10.1126/sciadv.abn9516
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发表时间:
2022-09-09
期刊:
影响因子:
13.6
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中科院分区:
文献类型:
--
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Understanding brain structure-function relationships, and their development and evolution, is central to neuroscience research. Here, we show that morphological differences in posterior cingulate cortex (PCC), a hub of functional brain networks, predict individual differences in macroanatomical, microstructural, and functional features of PCC. Manually labeling 4511 sulci in 572 hemispheres, we found a shallow cortical indentation (termed the inframarginal sulcus; ifrms) within PCC that is absent from neuroanatomical atlases yet colocalized with a focal, functional region of the lateral frontoparietal network implicated in cognitive control. This structural-functional coupling generalized to meta-analyses consisting of hundreds of studies and thousands of participants. Additional morphological analyses showed that unique properties of the ifrms differ across the life span and between hominoid species. These findings support a classic theory that shallow, tertiary sulci serve as landmarks in association cortices. They also beg the question: How many other cortical indentations have we missed? A previously uncharted brain structure links functional and anatomical organization and differs across the life span and species.
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