Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu.
Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu.
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DOI：
10.1186/1476-9255-7-36
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发表时间：
2010-07-26
期刊：
影响因子：
--
通讯作者：
Johnson WD
中科院分区：
文献类型：
--
作者：
Gupta AK;Johnson WD
肥胖是一种促炎症状态，通常与广泛的代谢改变相关，包括胰岛素抵抗和血压 (BP) 失调。这一系列事件在某种程度上解释了肥胖成年人对糖尿病和高血压等共病的易感性。我们假设全身促炎症负荷升高与血糖异常和血压失调相关。我们在一项减肥研究中分析了健康无病肥胖成年人（n = 35；女性 (W) 27，男性 (M) 8）的筛查人体测量和实验室测量结果。健康肥胖血糖正常（空腹血糖：FSG <100 mg/dL）的女性和男性与患有糖尿病前期的健康肥胖者（FSG 100-125 mg/dL）相比，在年龄（平均值±标准差：52±12 vs. 56±9 岁）、体重（95±11 vs. 99±13 kg）或腰围（108±10）方面没有显着差异。与 108 ± 11 厘米）。血糖正常组（n = 24；W = 19，M = 5）的 FSG 正常 92 ± 4 mg/dL，HbA1c 5.4 ± 0.3%，血压 118/75 mm Hg，但超敏 C 反应蛋白 (hs CRP) 升高 3.7 ± 3 mg/L，纤维蛋白原升高 472 ± 76 mg/dL。糖尿病前期组（n = 11；W = 8，M = 3）具有显着较高的 FSG（106 ± 3 mg/dL；p < 0.0001）、HbA1c（5.9 ± 0.5%；p < 0.002）、高血压前期（BP：127/80 mm Hg）和显着较高的 hs CRP（16.9 ± 9 mg/dL；p < 0.002）。 0.0001）和纤维蛋白原（599 ± 95 mg/dL；p < 0.0002）。在其他方面健康、无病的肥胖成年人中，较高程度的全身炎症与糖尿病前期和高血压前期相关。
Obesity is a pro-inflammatory state frequently associated with widespread metabolic alterations that include insulin resistance and deregulation of blood pressure (BP). This cascade of events in some measure explains the susceptibility of obese adults for co-morbid conditions like diabetes mellitus and hypertension. We hypothesized that an elevated systemic proinflammatory burden correlates with dysglycemia and deregulated blood pressure. We analyzed the screening anthropometric and laboratory measures from healthy disease free obese adults (n = 35; women (W) 27, men (M) 8) in a weight loss study. Healthy obese normoglycemic (fasting serum glucose: FSG <100 mg/dL) women and men compared with healthy obese with prediabetes (FSG 100-125 mg/dL) had no significant differences for age (Mean ± SD: 52 ± 12 vs. 56 ± 9 y), weight (95 ± 11 vs. 99 ± 13 kg), or waist circumference (108 ± 10 vs. 108 ± 11 cm). Normoglycemic group (n = 24; W = 19, M = 5) had normal FSG 92 ± 4 mg/dL, HbA1c 5.4 ± 0.3%, BP 118/75 mm Hg, but had elevated high sensitivity C-reactive protein (hs CRP) 3.7 ± 3 mg/L and fibrinogen 472 ± 76 mg/dL. The group with prediabetes (n = 11; W = 8, M = 3) with significantly higher FSG (106 ± 3 mg/dL; p < 0.0001), HbA1c (5.9 ± 0.5%; p < 0.002), had prehypertension (BP: 127/80 mm Hg) and significantly higher hs CRP (16.9 ± 9 mg/; p < 0.0001) and fibrinogen (599 ± 95 mg/dL; p < 0.0002). In otherwise healthy disease free obese adults, a higher degree of systemic inflammation is associated with prediabetes and prehypertension.
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5.1
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