Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model.
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model.
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嘌呤能 ATP 触发艾灸引起的对炎性疼痛模型的局部抗伤害作用。
DOI：
10.1007/s11302-021-09815-5
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发表时间：
2023-03
影响因子：
3.5
通讯作者：
Yu, Shu-Guang
中科院分区：
文献类型：
--
作者：
Yin, Hai-Yan;Fan, Ya-Peng;Liu, Juan;Li, Dao-Tong;Guo, Jing;Yu, Shu-Guang
已证明嘌呤能信号传导腺苷及其A1受体参与针刺（针刺疗法）镇痛的机制。然而，作为针灸家族中的主要成员，艾灸疗法的局部镇痛作用是否也与嘌呤能信号有关，目前尚不清楚。本研究采用艾灸对完全弗氏佐剂（CFA）诱导的炎性痛大鼠产生镇痛作用，并采用高效液相色谱法（HPLC）检测艾灸穴位嘌呤释放量。足三里穴肌肉注射ARL 67156抑制ATP的分解，可增强艾灸的镇痛作用;肌肉注射ATP酶，加速ATP的水解，可减弱艾灸的镇痛作用。提示ST_（36）穴嘌呤能ATP可能是针刺镇痛的有益因素。
Purinergic signalling adenosine and its A1 receptors have been demonstrated to get involved in the mechanism of acupuncture (needling therapy) analgesia. However, whether purinergic signalling would be responsible for the local analgesic effect of moxibustion therapy, the predominant member in acupuncture family procedures also could trigger analgesic effect on pain diseases, it still remains unclear. In this study, we applied moxibustion to generate analgesic effect on complete Freund’s adjuvant (CFA)-induced inflammatory pain rats and detected the purine released from moxibustioned-acupoint by high-performance liquid chromatography (HPLC) approach. Intramuscular injection of ARL67156 into the acupoint Zusanli (ST36) to inhibit the breakdown of ATP showed the analgesic effect of moxibustion was increased while intramuscular injection of ATPase to speed up ATP hydrolysis caused a reduced moxibustion-induced analgesia. These data implied that purinergic ATP at the location of ST36 acupoint is a potentially beneficial factor for moxibustion-induced analgesia.
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