Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedonia.
Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedonia.
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DOI：
10.1371/journal.pone.0006598
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发表时间：
2009-08-12
期刊：
影响因子：
3.7
通讯作者：
Zald DH
中科院分区：
文献类型：
--
作者：
Treadway MT;Buckholtz JW;Schwartzman AN;Lambert WE;Zald DH
在严重抑郁障碍(MDD)可能的精神病理内表型中，非享乐亚型尤其受到支持。快感缺乏通常被认为反映了异常的动机和对奖励的反应性。然而，由于缺乏对奖励动机的客观衡量，研究一直受到限制。我们提出了努力-奖励任务支出(EEFRT)，这是一种新的行为范式，作为探索人类基于努力的决策的一种手段。使用EEFRT，我们检验了基于努力的决策与特质快感缺乏相关的假设。61名本科生参加了这项实验。受试者完成了情绪和个性快感缺乏的自我报告，并完成了EEFRT。通过多项分析，我们发现快感缺乏症和愿意为回报付出努力之间存在显著的负相关关系。这些发现表明快感缺乏与奖励动机降低有关，并为EEFRT作为人类奖励动机和基于努力的决策的实验室行为测量提供了初步验证。
Of the putative psychopathological endophenotypes in major depressive disorder (MDD), the anhedonic subtype is particularly well supported. Anhedonia is generally assumed to reflect aberrant motivation and reward responsivity. However, research has been limited by a lack of objective measures of reward motivation. We present the Effort-Expenditure for Rewards Task (EEfRT or “effort”), a novel behavioral paradigm as a means of exploring effort-based decision-making in humans. Using the EEfRT, we test the hypothesis that effort-based decision-making is related to trait anhedonia. 61 undergraduate students participated in the experiment. Subjects completed self-report measures of mood and trait anhedonia, and completed the EEfRT. Across multiple analyses, we found a significant inverse relationship between anhedonia and willingness to expend effort for rewards. These findings suggest that anhedonia is specifically associated with decreased motivation for rewards, and provide initial validation for the EEfRT as a laboratory-based behavioral measure of reward motivation and effort-based decision-making in humans.
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