NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping.
NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping.
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DOI：
10.1007/s00335-012-9425-z
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发表时间：
2012-10
期刊：
影响因子：
2.5
通讯作者：
Wasserman, David H.
中科院分区：
文献类型：
--
作者：
Laughlin, Maren R.;Lloyd, K. C. Kent;Cline, Gary W.;Wasserman, David H.
小鼠代谢表型中心(MMPC)由美国国立卫生研究院(NIH)于2001年成立，旨在通过为糖尿病、肥胖症及其并发症的小鼠模型提供标准化、高质量的表型服务来促进生物医学研究。这样做的目的是让研究人员能够最大限度地利用实验室和高通量公共努力中生产的许多新的鼠标模型。这六个MMPC位于全国各地的大学，在完整的小鼠身上进行复杂的新陈代谢测试，并在收费的基础上对组织中的激素和分析物进行分析。测试由美国国立卫生研究院提供补贴，以减少老鼠研究人员的障碍。尽管来自这些测试的数据属于提交小鼠或组织的研究人员，但这些数据在发布后被归档到由MMPC协调和生物信息学股运行的公共数据库中。人们希望，使用标准方案在许多代谢性疾病小鼠模型上进行的实验数据将有助于理解这些复杂疾病的性质。目前的专业领域包括能量平衡和身体组成，胰岛素的作用和分泌，全身和组织的碳水化合物和脂肪代谢，心血管和肾脏功能，以及代谢途径动力学。除了提供服务外，MMPC工作人员还向研究人员提供专业知识和建议，并致力于开发和完善测试方案，以最大限度地满足当前科学发展的社区需求。测试技术通过出版物和年度课程进行传播。
The Mouse Metabolic Phenotyping Centers (MMPCs) were founded in 2001 by the National Institutes of Health (NIH) to advance biomedical research by providing the scientific community with standardized, high-quality phenotyping services for mouse models of diabetes, obesity, and their complications. The intent is to allow researchers to take optimum advantage of the many new mouse models produced in labs and in high-throughput public efforts. The six MMPCs are located at universities around the country and perform complex metabolic tests in intact mice and hormone and analyte assays in tissues on a fee-for-service basis. Testing is subsidized by the NIH in order to reduce the barriers for mouse researchers. Although data derived from these tests belong to the researcher submitting mice or tissues, these data are archived after publication in a public database run by the MMPC Coordinating and Bioinformatics Unit. It is hoped that data from experiments performed in many mouse models of metabolic diseases, using standard protocols, will be useful in understanding the nature of these complex disorders. The current areas of expertise include energy balance and body composition, insulin action and secretion, whole-body and tissue carbohydrate and lipid metabolism, cardiovascular and renal function, and metabolic pathway kinetics. In addition to providing services, the MMPC staff provides expertise and advice to researchers, and works to develop and refine test protocols to best meet the community’s needs in light of current scientific developments. Test technology is disseminated by publications and through annual courses.
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影响因子：
7.7
作者：
Berglund, Eric D.;Li, Candice Y.;Poffenberger, Greg;Ayala, Julio E.;Fueger, Patrick T.;Willis, Shannon E.;Jewell, Marybeth M.;Powers, Alvin C.;Wasserman, David H.
通讯作者：
Wasserman, David H.
影响因子：
29
作者：
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通讯作者：
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影响因子：
7.7
作者：
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通讯作者：
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影响因子：
9
作者：
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通讯作者：
Abumrad NN
DOI：
10.1111/j.1540-8175.2006.00356.x
发表时间：
2007-01-01
影响因子：
1.5
作者：
Rottman, Jeffrey N.;Ni, Gemin;Brown, Michael
通讯作者：
Brown, Michael