APOE-epsilon4 and aging of medial temporal lobe gray matter in healthy adults older than 50 years.
APOE-epsilon4 and aging of medial temporal lobe gray matter in healthy adults older than 50 years.
复制标题
APOE-epsilon4 与 50 岁以上健康成年人内侧颞叶灰质的衰老。
DOI：
10.1016/j.neurobiolaging.2014.05.011
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发表时间：
2014-11
影响因子：
4.2
通讯作者：
Weiner MW
中科院分区：
文献类型：
--
作者：
Taylor JL;Scanlon BK;Farrell M;Hernandez B;Adamson MM;Ashford JW;Noda A;Murphy GM Jr;Weiner MW
阿尔茨海默病 (AD) 会导致海马体和周围颞区萎缩。 APOE ε4 是迟发性 AD 的主要遗传风险因素，在 AD 生物标志物检测到淀粉样变性之前，它与这些区域的体积较小有关。为了检查 APOE ε4 与衰老的关系，我们进行了一项纵向 MRI 研究，涉及认知正常的成年人（25 名 APOE ε4 携带者和 31 名 ε3 纯合子），最初年龄为 51-75 岁。我们使用生长曲线分析，它可以提供生命初期和后期与 APOE ε4 相关的差异的信息。海马体积是主要结果；附近的内侧颞区是次要结果。 BDNF val66met 是次要协变量。 APOE ε4 携带者的初始海马体积明显小于 ε3 纯合子。尽管在整个样本中检测到与年龄相关的萎缩，但 APOE ε4 组的海马萎缩率并不更高。越来越多的证据表明，APOE ε4 对海马大小的影响在生命早期就开始了，这些发现进一步证明了这一点，强调了早期干预以增加储备的重要性。
Atrophy of the hippocampus and surrounding temporal regions occurs in Alzheimer’s disease (AD). APOE ε4, the major genetic risk factor for late-onset AD, has been associated with smaller volume in these regions before amyloidosis can be detected by AD biomarkers. To examine APOE ε4 effects in relation to aging, we performed a longitudinal MRI study involving cognitively normal adults (25 APOE ε4 carriers and 31 ε3 homozygotes), initially aged 51–75 years. We used growth curve analyses, which can provide information about APOE ε4-related differences initially and later in life. Hippocampal volume was the primary outcome; nearby medial temporal regions were secondary outcomes. BDNF val66met was a secondary covariate. APOE ε4 carriers had significantly smaller initial hippocampal volumes than ε3 homozygotes. Rate of hippocampal atrophy was not greater in the APOE ε4 group, even though age-related atrophy was detected in the overall sample. The findings add to the growing evidence that effects of APOE ε4 on hippocampal size begin early in life, underscoring the importance of early interventions to increase reserve.
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影响因子：
10.6
作者：
Christensen, GE;Joshi, SC;Miller, MI
通讯作者：
Miller, MI
影响因子：
9.9
作者：
Cohen, RM;Small, C;Sunderland, T
通讯作者：
Sunderland, T
DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
Erickson, Kirk I.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
2.4
作者：
Jak, Amy J.;Houston, Wes S.;Bondi, Mark W.
通讯作者：
Bondi, Mark W.
影响因子：
--
作者：
Khachaturian, AS;Corcoran, CD;Breitner, JCS
通讯作者：
Breitner, JCS